vialroom

#bloodwork 2025-06-10

Tuesday36 messages10 participantstimes are UTC
Highlights from this day
  • salt_bridge — on its own, no. with no pain, an isolated mildly raised lipase is a very common finding on these drugs 22:53
  • salt_bridge — there is a reason routine lipase monitoring in an asymptomatic person is not standard practice 23:03
  • salt_bridge — when there is pain that fits. severe, steady, upper abdomen, often boring into the back, with vomiting 23:07
  • salt_bridge — for the base rate question — in the head to head trial, adjudicated pancreatitis was rare on both drugs 23:12
  • karl_fischer — that is the correct amount of caution 23:18
TT

i pay privately for fasting insulin because nobody will order it for me otherwise

fasting insulin

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HL

most of the lipid improvement in my panel tracked the weight, not the drug

baseline, three months, then twice a year is what i settled on, thats just me

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right so what would make you stop and go and see somebody rather than post here

LT

ferritin and b12 fall quietly when you are barely eating. check them twice a year

NF

lipase came back just over the top of the reference range. am i about to get pancreatitis

SB

on its own, no. with no pain, an isolated mildly raised lipase is a very common finding on these drugs

asymptomatic enzyme elevations show up in the trial data and mostly go nowhere

SB

there is a reason routine lipase monitoring in an asymptomatic person is not standard practice

9
SB

when there is pain that fits. severe, steady, upper abdomen, often boring into the back, with vomiting

in that setting the number is genuinely useful, and you are not the person interpreting it

SB

for the base rate question — in the head to head trial, adjudicated pancreatitis was rare on both drugs

Cited study
Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes (SURPASS-2)
New England Journal of Medicine · 2021
tirzepatide produced greater A1c and weight reductions than semaglutide 1 mg; adjudicated pancreatitis was rare in both arms
SB

a handful of events across thousands of participants. i am not going to quote a rate from memory

SB

you do not ignore it. you tell whoever ordered it, and you stop ordering it for fun

SB

same story, less specific. amylase moves for salivary reasons too

KF

if you only get one, lipase. if you get neither and you have no symptoms, also fine

CC

apob is the better marker and it is harder to get. i track both because i can only get one reliably

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