Compounds
#cagrilintide
Cagrilintide, amylin analogues, and the combination story.
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The amylin half of the combination story: cagrilintide alone, cagrilintide with semaglutide, the REDEFINE programme, a nausea profile that most people describe as different rather than worse, and a titration that generally wants to be slower than people expect.
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Amylin analogues are not GLP-1 agonists and do not behave like them. If you are treating cagrilintide as "another sema" you will get the titration wrong.
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2026-06-30titrating dead slow36 msgs · 8 people2026-06-29slightly off topic but the reason nausea reads differently is timing, mine arrived on the second day rather than the…14 msgs · 5 people2026-06-28i keep the two on separate days so if something goes wrong i have a chance of knowing which, we shall see held at 10…44 msgs · 8 people2026-06-27anyone got two Medutest results on the same KP lot for this21 msgs · 4 people2026-06-26monotherapy here13 msgs · 3 people2026-06-24fullness rather than nausea22 msgs · 5 people2026-06-23has REDEFINE reported or are people quoting earlier work40 msgs · 9 people2026-06-21different not less54 msgs · 11 people2026-06-20anyone got two Janoshik results on the same GGPeps lot for this46 msgs · 9 people2026-06-19combination GI was worse than either alone for me, which is not what i had read anywhere17 msgs · 4 people2026-06-16slightly off topic but is the slower titration because of nausea or something else43 msgs · 13 people2026-06-12held mine a while20 msgs · 4 people2026-06-11dropped the GLP-1 and stayed on this alone for 16 months, appetite held but weight barely moved, anyway24 msgs · 6 people2026-06-10is anyone running this on its own or is it all CagriSema in here32 msgs · 8 people2026-06-09amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist21 msgs · 4 people2026-06-08slower than the others28 msgs · 6 people2026-06-07how do people separate which of the two is doing what in a combination39 msgs · 10 people2026-06-05REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work, n of 1 obviously50 msgs · 10 people2026-06-03its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake31 msgs · 8 people2026-06-02anyone holding at 10 for a while before stepping54 msgs · 10 people2026-05-31separate days41 msgs · 12 people2026-05-27cant separate them30 msgs · 9 people2026-05-24the fullness thing is the part people describe differently, food stops being interesting rather than repellent, still…18 msgs · 3 people2026-05-23i keep the two on separate days so if something goes wrong i have a chance of knowing which34 msgs · 5 people2026-05-22anyone dosing this on a different day to their tirzepatide30 msgs · 9 people2026-05-21REDEFINE is the trial44 msgs · 10 people2026-05-20changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing24 msgs · 7 people2026-05-18titrating dead slow13 msgs · 3 people2026-05-17monotherapy was underwhelming for me and i say that as someone who wanted it to work stopped for 12 months and the…13 msgs · 4 people2026-05-16combination GI was worse than either alone for me, which is not what i had read anywhere47 msgs · 9 people
Threads spun off from this channel
anyone stopped the GLP-1 and kept only this2026-06-30 · 15 msgsback after 2 months, is monotherapy still a minority2026-06-23 · 12 msgsfor the archive i keep the two on separate2026-06-19 · 10 msgsi was sceptical about monotherapy and after 26 months2026-06-16 · 13 msgswent slower because the first step gave me two2026-06-02 · 17 msgsthe numbers everyone quotes come from the combination, so2026-05-22 · 10 msgsis the combination just the two dosed together or2026-05-20 · 9 msgsweekly for me, same day every week, no reason2026-05-04 · 7 msgscombination GI was worse than either alone for me2026-04-22 · 13 msgschanged my mind on this, i started thinking amylin2026-04-18 · 10 msgsdosing them on different days made no difference i2026-04-14 · 12 msgsmonotherapy question, did appetite move for you without a2026-04-11 · 17 msgsfor the archive did anyone add this to an2026-03-30 · 14 msgswhats the recon people use, 5 in 1.5ml2026-03-28 · 16 msgsfollow up i titrated over twice as many weeks2026-03-07 · 13 msgswhats the recon people use, 15 in 3ml2026-02-11 · 6 msgsstopped for 1 months and the fullness went within2026-01-08 · 14 msgsits an amylin analogue, different receptor family, so treating2025-11-01 · 6 msgsis anyone running this on its own or is2025-08-18 · 9 msgsi was sceptical about monotherapy and after 15 months2025-08-09 · 17 msgsis there a reason people titrate this over more2025-07-25 · 17 msgsdid the nausea feel different to you or just2025-04-19 · 5 msgsweekly for me, same day every week, no reason2025-03-08 · 12 msgshow many weeks before you noticed anything on monotherapy2024-11-10 · 8 msgs