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#cagrilintide 2025-09-04

Thursday15 messages5 participantstimes are UTC
Highlights from this day
  • taper_tess — has REDEFINE reported or are people quoting earlier work 15:10
  • split_the_cost — if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way 15:48
  • taper_tess — changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing 15:49
  • taper_tess — back after 5 months, is monotherapy still a minority thing here 15:52
  • taper_tess — i was sceptical about monotherapy and after 26 months im still sceptical, just less so, n of 1 obviously 16:21
TT

has REDEFINE reported or are people quoting earlier work

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ST

if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way

TT

changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing

back after 5 months, is monotherapy still a minority thing here

Cited study
Efficacy and Safety of Cagrilintide in Adults with Overweight or Obesity — Phase 2
The Lancet · 2021
Cagrilintide monotherapy, dose ranging. The combination trials came later.

amylin not glp-1

MM

the fullness effect hasnt faded over 21 months, unlike my semaglutide appetite curve

TT

how slow are people titrating this compared to retatrutide

MM

the nausea felt different rather than less, more fullness and less of the queasy wave

TT

i was sceptical about monotherapy and after 26 months im still sceptical, just less so, n of 1 obviously

ST

underwhelming honestly

Cited study
Efficacy and Safety of Cagrilintide in Adults with Overweight or Obesity — Phase 2
The Lancet · 2021
Cagrilintide monotherapy, dose ranging. The combination trials came later.
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