i titrated over twice as many weeks as i did on semaglutide and that was right for me
#cagrilintide 2025-10-19
Sunday48 messages9 participantstimes are UTC
Highlights from this day
- snac_and_water — if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way 08:17
- protein_floor — noticed something around week 10 on monotherapy, well after i had given up expecting to 09:23
- cross_border_cam — is the nausea profile genuinely different or am i imagining it 10:51
combination for me
the fullness effect hasnt faded over 22 months, unlike my semaglutide appetite curve
back after 5 months, is monotherapy still a minority thing here
if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way
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CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it
did the combination change your GI compared to the GLP-1 alone
different not less
did anyone add this to an existing semaglutide dose rather than starting both
is the slower titration because of nausea or something else
[edited]is there a reason people titrate this over more weeks than the others
two Medutest results on the same QSC lot came back 99.4 and 98.1, closer than i expected
anyone holding at 7.5 for a while before stepping
you cannot tell which of the two is doing what in a combination and i stopped pretending i could, thats just me
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dosing them on different days made no difference i could detect
underwhelming honestly
does amylin do something about fullness that the GLP-1 doesnt
how many weeks before you noticed anything on monotherapy
is anyone running this on its own or is it all CagriSema in here
weekly for me, same day every week, no reason beyond habit
cagrisema thats it
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slower than the others
the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair
noticed something around week 10 on monotherapy, well after i had given up expecting to
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went slower because the first step gave me two rough days and i took that as information
held mine a while
titrating dead slow
quick one dropped the GLP-1 and stayed on this alone for 1 months, appetite held but weight barely moved
has REDEFINE reported or are people quoting earlier work
quick one changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing, anyway
follow up combination GI was worse than either alone for me, which is not what i had read anywhere
monotherapy here
Digest for the week of 2024-12-22 has been published.
anyone dosing this on a different day to their semaglutide
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unrelated but $240 for a 10 vial and it lasts me longer than the GLP-1 does at my doses
unrelated but i said earlier this year that monotherapy did nothing for me, and at a higher dose it did something, still working it out
the nausea felt different rather than less, more fullness and less of the queasy wave
right so how slow are people titrating this compared to cagrilintide
monotherapy did work for me, just slower and smaller than i expected
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is the nausea profile genuinely different or am i imagining it
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separate days
genuine question anyone got two Janoshik results on the same KP lot for this
the slower titration in here is community habit as much as anything, the trials had their own schedule
cant separate them
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lost 101lb over 2 months on the combination and i genuinely cannot apportion it
REDEFINE is the trial
i keep the two on separate days so if something goes wrong i have a chance of knowing which
amylin not glp-1