added it to an existing retatrutide dose rather than starting both, which made attribution possible, not advice obviously
#cagrilintide 2025-10-21
Tuesday41 messages9 participantstimes are UTC
Highlights from this day
- two_three_lifts — the nausea felt different rather than less, more fullness and less of the queasy wave 16:45
- salt_bridge — follow up the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair, for what its worth 17:44
- comment_fatigue — anyone dosing this on a different day to their cagrilintide 20:12
the nausea felt different rather than less, more fullness and less of the queasy wave
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sorry to jump in REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work
monotherapy here
anyone got two VendorInvestigate results on the same CPC lot for this
the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing
anyone stopped the GLP-1 and kept only this
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whats REDEFINE testing exactly
the slower titration in here is community habit as much as anything, the trials had their own schedule
underwhelming honestly
follow up the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair, for what its worth
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first_and_last_fourthe combination is the thing with trial data behind it, monotherapy in here is mostly…
does amylin do something about fullness that the GLP-1 doesnt
monotherapy did work for me, just slower and smaller than i expected, i could be wrong
dosing them on different days made no difference i could detect
anyone holding at 10 for a while before stepping
combination for me
amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist
REDEFINE is the trial
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follow up amylin analogue, so its not a GLP-1 at all right
slower than the others
the fullness thing is the part people describe differently, food stops being interesting rather than repellent, from memory
i titrated over twice as many weeks as i did on semaglutide and that was right for me
[edited]changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing, i could be wrong
dosing them on different days made no difference i could detect
[edited]separate days
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its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake
nobody should copy my schedule, im describing it because people asked what a slow ramp looks like
unrelated but two PeptideMeter results on the same TFC lot came back 98.1 and 96.8, closer than i expected
cagrisema thats it
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went slower because the first step gave me two rough days and i took that as information
*Medutest not the other one
CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it, happy to be corrected
whats the recon people use, 2 in 0.5ml
did anyone find monotherapy underwhelming
weekly for me, same day every week, no reason beyond habit
20 in 1ml gives 8mg/ml which is what i use, purely because the units come out round
first_and_last_fourchanged my mind on this, i started thinking amylin was the interesting bit and now i…
genuine question is 2.4 the number for this too or am i confusing compounds
i keep the two on separate days so if something goes wrong i have a chance of knowing which
*Janoshik not the other one
is the slower titration because of nausea or something else