held mine a while
[edited]#cagrilintide 2025-11-18
Tuesday36 messages9 participantstimes are UTC
Highlights from this day
- non_scale_win — went slower because the first step gave me two rough days and i took that as information, anyway 19:29
- vik_verifies — lost 11lb over 7 months on the combination and i genuinely cannot apportion it held at 7.5 for 9 months on monotherapy before i touched it again 19:30
- VialBot — Reminder for non_scale_win: dose day is today. Set 7 days ago. 19:42
- non_scale_win — the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair 20:15
is 2.4 the number for this too or am i confusing compounds
how do people separate which of the two is doing what in a combination
slower than the others
⚠️10
fullness rather than nausea
🧪16
different not less
monotherapy here
does amylin do something about fullness that the GLP-1 doesnt
held at 7.5 for 4 months on monotherapy before i touched it again
went slower because the first step gave me two rough days and i took that as information, anyway
📉2
lost 11lb over 7 months on the combination and i genuinely cannot apportion it
held at 7.5 for 9 months on monotherapy before i touched it again
if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way
Reminder for non_scale_win: dose day is today. Set 7 days ago.
amylin not glp-1
combination for me
titrating dead slow
£94 for a 5 vial and it lasts me longer than the GLP-1 does at my doses
cant separate them
separate days
how slow are people titrating this compared to retatrutide
thats the phase 3 one
the reason nausea reads differently is timing, mine arrived on the second day rather than the first
sorry to jump in its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake
CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it
the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair
📈9❤️5
the slower titration in here is community habit as much as anything, the trials had their own schedule
combination GI was worse than either alone for me, which is not what i had read anywhere, i could be wrong
noticed something around week 33 on monotherapy, well after i had given up expecting to
the fullness effect hasnt faded over 26 months, unlike my semaglutide appetite curve
underwhelming honestly
anyone holding at 10 for a while before stepping
anyone dosing this on a different day to their tirzepatide
did anyone add this to an existing retatrutide dose rather than starting both
REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work
stopped for 3 months and the fullness went within a fortnight of the last dose
dosing them on different days made no difference i could detect