monotherapy was underwhelming for me and i say that as someone who wanted it to work
#cagrilintide 2026-03-20
Friday45 messages8 participantstimes are UTC
Highlights from this day
- comment_fatigue — i keep the two on separate days so if something goes wrong i have a chance of knowing which 18:14
- fridge_six_two — anyone got two Medutest results on the same CPC lot for this 19:43
- nausea_window — slightly off topic but is there a reason people titrate this over more weeks than the others 21:44
amylin analogue, so its not a GLP-1 at all right
different not less
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underwhelming honestly
fullness rather than nausea
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is the slower titration because of nausea or something else
monotherapy question, did appetite move for you without a GLP-1 alongside
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anyone holding at 2.4 for a while before stepping
i keep the two on separate days so if something goes wrong i have a chance of knowing which
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amylin not glp-1
has REDEFINE reported or are people quoting earlier work
update on the earlier thing back after 20 months, is monotherapy still a minority thing here
*VendorInvestigate not the other one
weekly for me, same day every week, no reason beyond habit
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cant separate them
did the combination change your GI compared to the GLP-1 alone
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nobody should copy my schedule, im describing it because people asked what a slow ramp looks like
£120 for a 15 vial and it lasts me longer than the GLP-1 does at my doses
anyone stopped the GLP-1 and kept only this
*VendorInvestigate not the other one
noticed something around week 30 on monotherapy, well after i had given up expecting to
two Medutest results on the same Homopeptide lot came back 99 and 96.8, closer than i expected
lost 8lb over 2 months on the combination and i genuinely cannot apportion it
i said earlier this year that monotherapy did nothing for me, and at a higher dose it did something
nobody should copy my schedule, im describing it because people asked what a slow ramp looks like
how do people separate which of the two is doing what in a combination
quick one amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist
thats the phase 3 one
anyone got two Medutest results on the same CPC lot for this
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while im here the fullness effect hasnt faded over 21 months, unlike my semaglutide appetite curve
combination for me
the reason nausea reads differently is timing, mine arrived on the second day rather than the first
the nausea felt different rather than less, more fullness and less of the queasy wave
unrelated but combination GI was worse than either alone for me, which is not what i had read anywhere
dropped the GLP-1 and stayed on this alone for 22 months, appetite held but weight barely moved, i could be wrong
does amylin do something about fullness that the GLP-1 doesnt
anyone dosing this on a different day to their semaglutide
titrating dead slow
unrelated but the slower titration in here is community habit as much as anything, the trials had their own schedule
added it to an existing cagrilintide dose rather than starting both, which made attribution possible
went slower because the first step gave me two rough days and i took that as information
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the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing, take that with a pinch of salt
its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake
i was sceptical about monotherapy and after 25 months im still sceptical, just less so
separate days
slightly off topic but is there a reason people titrate this over more weeks than the others
peptidemeter-summary-g-0641.pdf
2 pages · 480 KB · not retained in the public archive
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REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work
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