follow up the fullness thing is the part people describe differently, food stops being interesting rather than repellent
its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake
#cagrilintide 2025-07-12
Saturday29 messages5 participantstimes are UTC
Highlights from this day
- comment_fatigue — follow up the fullness thing is the part people describe differently, food stops being interesting rather than repellent its an amylin analogue, different receptor… 13:25
- unsolicited_dm — right so changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing 14:39
- luerlok — if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way 15:13
- unsolicited_dm — anyone dosing this on a different day to their retatrutide 15:31
- unsolicited_dm — is anyone running this on its own or is it all CagriSema in here 15:41
combination for me
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monotherapy was underwhelming for me and i say that as someone who wanted it to work
while im here is the nausea profile genuinely different or am i imagining it
quick one the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair, i have it written down somewhere
right so changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing
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i said earlier this year that monotherapy did nothing for me, and at a higher dose it did something
i was sceptical about monotherapy and after 17 months im still sceptical, just less so
how slow are people titrating this compared to tirzepatide
the reason nausea reads differently is timing, mine arrived on the second day rather than the first
combination GI was worse than either alone for me, which is not what i had read anywhere
monotherapy did work for me, just slower and smaller than i expected
nobody should copy my schedule, im describing it because people asked what a slow ramp looks like
if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way
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anyone dosing this on a different day to their retatrutide
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is anyone running this on its own or is it all CagriSema in here
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£120 for a 5 vial and it lasts me longer than the GLP-1 does at my doses
right so anyone holding at 10 for a while before stepping
underwhelming honestly
[edited]cant separate them
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coming back to this the slower titration in here is community habit as much as anything, the trials had their own schedule, happy to be corrected
held mine a while
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held at 0.25 for 7 months on monotherapy before i touched it again
did anyone add this to an existing retatrutide dose rather than starting both
noticed something around week 9 on monotherapy, well after i had given up expecting to
different not less
thats the phase 3 one
[edited]i keep the two on separate days so if something goes wrong i have a chance of knowing which
did the combination change your GI compared to the GLP-1 alone