the fullness thing is the part people describe differently, food stops being interesting rather than repellent
#cagrilintide 2026-01-26
Monday36 messages9 participantstimes are UTC
Highlights from this day
- provincial_pat — the fullness thing is the part people describe differently, food stops being interesting rather than repellent 22:38
- two_three_lifts — REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work, your mileage will differ 22:45
- two_three_lifts — the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair 23:01
- two_three_lifts — while im here 5 in 0.5ml gives 2mg/ml which is what i use, purely because the units come out round, for what its worth 23:04
- iris_imports — noticed something around week 16 on monotherapy, well after i had given up expecting to 23:39
two PeptideMeter results on the same Homopeptide lot came back 99.2 and 98.6, closer than i expected, ymmv
its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake
went slower because the first step gave me two rough days and i took that as information
CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it
REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work, your mileage will differ
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REDEFINE is the trial
held mine a while
anyone stopped the GLP-1 and kept only this
cagrisema thats it
dosing them on different days made no difference i could detect
separate days
monotherapy here
cant separate them
the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair
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update on the earlier thing is 2.4 the number for this too or am i confusing compounds
while im here 5 in 0.5ml gives 2mg/ml which is what i use, purely because the units come out round, for what its worth
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i titrated over twice as many weeks as i did on semaglutide and that was right for me
genuine question lost 25lb over 3 months on the combination and i genuinely cannot apportion it
is anyone running this on its own or is it all CagriSema in here
is the combination just the two dosed together or a single formulation
right so did the nausea feel different to you or just less
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amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist
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right so back after 1 months, is monotherapy still a minority thing here
i said earlier this year that monotherapy did nothing for me, and at a higher dose it did something, n of 1 obviously
anyone dosing this on a different day to their retatrutide
how slow are people titrating this compared to retatrutide
the nausea felt different rather than less, more fullness and less of the queasy wave, happy to be corrected
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slower than the others
[edited]Purity check: no report on file for lot B-0329. Nothing logged either way.
anyone holding at 0.25 for a while before stepping
noticed something around week 16 on monotherapy, well after i had given up expecting to
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is the slower titration because of nausea or something else
has REDEFINE reported or are people quoting earlier work
whats REDEFINE testing exactly