i keep the two on separate days so if something goes wrong i have a chance of knowing which
fridge-temps.csv
580 rows · not retained in the public archive
#cagrilintide 2026-05-23
Saturday34 messages5 participantstimes are UTC
Highlights from this day
amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist, someone check my working
stopped for 23 months and the fullness went within a fortnight of the last dose
amylin analogue, so its not a GLP-1 at all right
🧊9⚠️12
went slower because the first step gave me two rough days and i took that as information
combination for me
whats REDEFINE testing exactly
noticed something around week 15 on monotherapy, well after i had given up expecting to, thats one data point
lost 78lb over 13 months on the combination and i genuinely cannot apportion it
you cannot tell which of the two is doing what in a combination and i stopped pretending i could
update on the earlier thing is anyone running this on its own or is it all CagriSema in here
the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing
i said earlier this year that monotherapy did nothing for me, and at a higher dose it did something, not advice obviously
dosing them on different days made no difference i could detect
[edited]held at 1 for 7 months on monotherapy before i touched it again
anyone dosing this on a different day to their retatrutide
added it to an existing cagrilintide dose rather than starting both, which made attribution possible
dropped the GLP-1 and stayed on this alone for 11 months, appetite held but weight barely moved
follow up is there a reason people titrate this over more weeks than the others
2 in 1ml gives 2.5mg/ml which is what i use, purely because the units come out round
Batch lookup C-4402: 8 independent reports on file, earliest 2025-11-16.
fullness rather than nausea
does amylin do something about fullness that the GLP-1 doesnt
😂2
REDEFINE is the trial
🔥3📉1
monotherapy was underwhelming for me and i say that as someone who wanted it to work
✅9📈10
whats the recon people use, 30 in 0.5ml
underwhelming honestly
📉8👍7🎉14
the fullness thing is the part people describe differently, food stops being interesting rather than repellent
monotherapy did work for me, just slower and smaller than i expected
[redacted at member request] · archive policy
if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way
how many weeks before you noticed anything on monotherapy
site-rotation-map.png
1000 × 700 · 694 KB · not retained in the public archive
follow up nobody should copy my schedule, im describing it because people asked what a slow ramp looks like, from memory
does the fullness effect fade the way appetite suppression does
the fullness effect hasnt faded over 21 months, unlike my semaglutide appetite curve
the fullness effect hasnt faded over 1 months, unlike my semaglutide appetite curve
[edited]