amylin not glp-1
#cagrilintide 2026-03-30
Monday32 messages8 participantstimes are UTC
Highlights from this day
- oli_orals — whats REDEFINE testing exactly 09:09
- reship_rita — you cannot tell which of the two is doing what in a combination and i stopped pretending i could, your mileage will differ 09:12
- septum_sal — sorry to jump in is the weekly schedule the same here 09:14
- month_six_me — the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing 10:12
monotherapy did work for me, just slower and smaller than i expected, i could be wrong
REDEFINE is the trial
the reason nausea reads differently is timing, mine arrived on the second day rather than the first
how do people separate which of the two is doing what in a combination
different not less
amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist
is the combination just the two dosed together or a single formulation
its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake
On this day 4 years ago this channel logged 11 messages.
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cant separate them
for the archive did anyone add this to an existing semaglutide dose rather than starting both
is 2.4 the number for this too or am i confusing compounds
whats REDEFINE testing exactly
you cannot tell which of the two is doing what in a combination and i stopped pretending i could, your mileage will differ
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sorry to jump in is the weekly schedule the same here
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i said earlier this year that monotherapy did nothing for me, and at a higher dose it did something, your mileage will differ
cagrisema thats it
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dropped the GLP-1 and stayed on this alone for 18 months, appetite held but weight barely moved, from memory
nobody should copy my schedule, im describing it because people asked what a slow ramp looks like
does amylin do something about fullness that the GLP-1 doesnt
coming back to this is anyone running this on its own or is it all CagriSema in here
held at 0.5 for 2 months on monotherapy before i touched it again
the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing
janoshik-f-1330.pdf
2 pages · 311 KB · not retained in the public archive
did the nausea feel different to you or just less
right so CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it
titrating dead slow
Reminder for septum_sal: dose day is today. Set 3 days ago.
weekly for me, same day every week, no reason beyond habit
slower than the others
fridge-thermometer.png
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has REDEFINE reported or are people quoting earlier work