back after 24 months, is monotherapy still a minority thing here
#cagrilintide 2026-03-29
Sunday47 messages8 participantstimes are UTC
Highlights from this day
- verify_or_dont — back after 24 months, is monotherapy still a minority thing here 19:03
- same_chromato — its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake 19:35
- nettle_notes — the fullness effect hasnt faded over 1 months, unlike my semaglutide appetite curve 20:53
- verify_or_dont — the slower titration in here is community habit as much as anything, the trials had their own schedule 20:54
underwhelming honestly
held at 1 for 4 months on monotherapy before i touched it again
went slower because the first step gave me two rough days and i took that as information
nobody should copy my schedule, im describing it because people asked what a slow ramp looks like
the nausea felt different rather than less, more fullness and less of the queasy wave
weekly for me, same day every week, no reason beyond habit
lost 69lb over 13 months on the combination and i genuinely cannot apportion it
its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake
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cant separate them
the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing
combination GI was worse than either alone for me, which is not what i had read anywhere
separate days
added it to an existing tirzepatide dose rather than starting both, which made attribution possible
the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair
the reason nausea reads differently is timing, mine arrived on the second day rather than the first
monotherapy was underwhelming for me and i say that as someone who wanted it to work
whats the recon people use, 40 in 1ml
dosing them on different days made no difference i could detect
unrelated but monotherapy did work for me, just slower and smaller than i expected
i titrated over twice as many weeks as i did on semaglutide and that was right for me
held mine a while
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stopped for 9 months and the fullness went within a fortnight of the last dose
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two Janoshik results on the same SWB lot came back 97.4 and 98.1, closer than i expected
did the nausea feel different to you or just less
REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work
quick one if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way
how many weeks before you noticed anything on monotherapy
is the nausea profile genuinely different or am i imagining it
is the slower titration because of nausea or something else
the fullness thing is the part people describe differently, food stops being interesting rather than repellent, ill dig out the number
you cannot tell which of the two is doing what in a combination and i stopped pretending i could
*Medutest not the other one
follow up i was sceptical about monotherapy and after 19 months im still sceptical, just less so
[edited]REDEFINE is the trial
monotherapy here
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CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it
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thats the phase 3 one
the fullness effect hasnt faded over 1 months, unlike my semaglutide appetite curve
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the slower titration in here is community habit as much as anything, the trials had their own schedule
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different not less
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slower than the others
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noticed something around week 24 on monotherapy, well after i had given up expecting to
amylin not glp-1
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titrating dead slow
for the archive changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing
amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist