slower than the others
#cagrilintide 2026-03-28
Saturday49 messages10 participantstimes are UTC
Highlights from this day
- LC_MS_Lena — back after 5 months, is monotherapy still a minority thing here 18:52
- provincial_pat — whats the recon people use, 5 in 1.5ml 20:01
- no_appetite_nia — did the nausea feel different to you or just less 20:16
- back_from_away — did anyone add this to an existing semaglutide dose rather than starting both 23:10
stopped for 22 months and the fullness went within a fortnight of the last dose
back after 5 months, is monotherapy still a minority thing here
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the nausea felt different rather than less, more fullness and less of the queasy wave
went slower because the first step gave me two rough days and i took that as information
REDEFINE is the trial
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monotherapy question, did appetite move for you without a GLP-1 alongside
identity_shiftwent slower because the first step gave me two rough days and i took that as information
its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake
underwhelming honestly
added it to an existing cagrilintide dose rather than starting both, which made attribution possible
different not less
is anyone running this on its own or is it all CagriSema in here
held at 2.5 for 5 months on monotherapy before i touched it again
unrelated but whats REDEFINE testing exactly
the reason nausea reads differently is timing, mine arrived on the second day rather than the first
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i titrated over twice as many weeks as i did on semaglutide and that was right for me
the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing
you cannot tell which of the two is doing what in a combination and i stopped pretending i could
is the weekly schedule the same here
anyone stopped the GLP-1 and kept only this
$120 for a 5 vial and it lasts me longer than the GLP-1 does at my doses
fullness rather than nausea
amylin not glp-1
combination GI was worse than either alone for me, which is not what i had read anywhere
i was sceptical about monotherapy and after 15 months im still sceptical, just less so
unrelated but the reason nausea reads differently is timing, mine arrived on the second day rather than the first, happy to be corrected
did the nausea feel different to you or just less
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separate days
i keep the two on separate days so if something goes wrong i have a chance of knowing which
20 in 2.5ml gives 8mg/ml which is what i use, purely because the units come out round
monotherapy did work for me, just slower and smaller than i expected
i said earlier this year that monotherapy did nothing for me, and at a higher dose it did something
how do people separate which of the two is doing what in a combination
is 2.4 the number for this too or am i confusing compounds
dropped the GLP-1 and stayed on this alone for 26 months, appetite held but weight barely moved
the slower titration in here is community habit as much as anything, the trials had their own schedule
if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way
*that should say weekly
cant separate them
update on the earlier thing weekly for me, same day every week, no reason beyond habit
combination for me
does the fullness effect fade the way appetite suppression does
cagrisema thats it
dosing them on different days made no difference i could detect
is the combination just the two dosed together or a single formulation
two Medutest results on the same HJ lot came back 99.4 and 98.1, closer than i expected
CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it
monotherapy was underwhelming for me and i say that as someone who wanted it to work, for what its worth
nobody should copy my schedule, im describing it because people asked what a slow ramp looks like
no_appetite_niai was sceptical about monotherapy and after 15 months im still sceptical, just less so
did anyone add this to an existing semaglutide dose rather than starting both
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