CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it
#cagrilintide 2026-03-26
Thursday33 messages7 participantstimes are UTC
Highlights from this day
- no_chargeback — i was sceptical about monotherapy and after 9 months im still sceptical, just less so 10:06
- no_chargeback — its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake 10:14
- bench_notes — the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair, n of 1 obviously 11:03
- bench_notes — added it to an existing tirzepatide dose rather than starting both, which made attribution possible, we shall see 12:15
cant separate them
different not less
anyone holding at 2.4 for a while before stepping
held mine a while
20 in 1ml gives 2mg/ml which is what i use, purely because the units come out round
slower than the others
does the fullness effect fade the way appetite suppression does
you cannot tell which of the two is doing what in a combination and i stopped pretending i could
monotherapy here
i was sceptical about monotherapy and after 9 months im still sceptical, just less so
👍10
its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake
how slow are people titrating this compared to cagrilintide
lost 44lb over 18 months on the combination and i genuinely cannot apportion it
did the nausea feel different to you or just less
*PeptideMeter not the other one
the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair, n of 1 obviously
monotherapy question, did appetite move for you without a GLP-1 alongside
ok so is the nausea profile genuinely different or am i imagining it
added it to an existing tirzepatide dose rather than starting both, which made attribution possible, we shall see
noticed something around week 5 on monotherapy, well after i had given up expecting to, from memory
REDEFINE is the trial
monotherapy was underwhelming for me and i say that as someone who wanted it to work
genuine question monotherapy did work for me, just slower and smaller than i expected
i keep the two on separate days so if something goes wrong i have a chance of knowing which
went slower because the first step gave me two rough days and i took that as information
anyone dosing this on a different day to their retatrutide
held at 5 for 5 months on monotherapy before i touched it again
stopped for 23 months and the fullness went within a fortnight of the last dose
the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing
separate days
the slower titration in here is community habit as much as anything, the trials had their own schedule