slightly off topic but is the slower titration because of nausea or something else
#cagrilintide 2026-06-16
Tuesday43 messages13 participantstimes are UTC
Highlights from this day
- constipation_con — monotherapy did work for me, just slower and smaller than i expected 20:36
- vale_vials — held at 1.7 for 8 months on monotherapy before i touched it again 21:00
- two_four_ceiling — i was sceptical about monotherapy and after 26 months im still sceptical, just less so 22:14
- VialBot — Verification log updated: WWB — evidence added, status unchanged. 22:47
cagrisema thats it
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if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way
monotherapy was underwhelming for me and i say that as someone who wanted it to work
combination for me
did the combination change your GI compared to the GLP-1 alone
monotherapy did work for me, just slower and smaller than i expected
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did anyone add this to an existing tirzepatide dose rather than starting both
constipation_conmonotherapy was underwhelming for me and i say that as someone who wanted it to work
quick one weekly for me, same day every week, no reason beyond habit
did the nausea feel different to you or just less
anyone stopped the GLP-1 and kept only this
back after 1 months, is monotherapy still a minority thing here
REDEFINE is the trial
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monotherapy here
changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing
held at 1.7 for 8 months on monotherapy before i touched it again
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added it to an existing cagrilintide dose rather than starting both, which made attribution possible
thats the phase 3 one
nobody should copy my schedule, im describing it because people asked what a slow ramp looks like
combination GI was worse than either alone for me, which is not what i had read anywhere
the slower titration in here is community habit as much as anything, the trials had their own schedule
underwhelming honestly
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for the archive the nausea felt different rather than less, more fullness and less of the queasy wave
stopped for 9 months and the fullness went within a fortnight of the last dose
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different not less
fullness rather than nausea
the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair
noticed something around week 32 on monotherapy, well after i had given up expecting to
the reason nausea reads differently is timing, mine arrived on the second day rather than the first, ill dig out the number
REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work
Inter-lab diff for lot A-2601: 98.1% vs 96.8%. Within expected range.
is the weekly schedule the same here
i was sceptical about monotherapy and after 26 months im still sceptical, just less so
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is anyone running this on its own or is it all CagriSema in here
dosing them on different days made no difference i could detect
40 in 0.5ml gives 2.5mg/ml which is what i use, purely because the units come out round
does the fullness effect fade the way appetite suppression does
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slower than the others
its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake
the reason nausea reads differently is timing, mine arrived on the second day rather than the first
separate days
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amylin not glp-1
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