CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it
#cagrilintide 2025-08-25
Monday15 messages5 participantstimes are UTC
Highlights from this day
- nausea_window — combination GI was worse than either alone for me, which is not what i had read anywhere 20:30
- nausea_window — the nausea felt different rather than less, more fullness and less of the queasy wave two VendorInvestigate results on the same KP lot came back 99.2 and 96.8, closer… 20:46
- the_bet_2026 — the slower titration in here is community habit as much as anything, the trials had their own schedule 21:42
- VialBot — New independent result logged — WWB, lot B-0329, purity 98.6% (Janoshik). 21:50
how do people separate which of the two is doing what in a combination
combination GI was worse than either alone for me, which is not what i had read anywhere
transit-times.csv
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the nausea felt different rather than less, more fullness and less of the queasy wave
two VendorInvestigate results on the same KP lot came back 99.2 and 96.8, closer than i expected
slightly off topic but the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing
$94 for a 40 vial and it lasts me longer than the GLP-1 does at my doses
is the slower titration because of nausea or something else
[edited]changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing, we shall see
back after 7 months, is monotherapy still a minority thing here
i said earlier this year that monotherapy did nothing for me, and at a higher dose it did something
did the nausea feel different to you or just less
nausea_windowcombination GI was worse than either alone for me, which is not what i had read anywhere
monotherapy question, did appetite move for you without a GLP-1 alongside
the slower titration in here is community habit as much as anything, the trials had their own schedule
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New independent result logged — WWB, lot B-0329, purity 98.6% (Janoshik).
anyone stopped the GLP-1 and kept only this