underwhelming honestly
[edited]#cagrilintide 2026-05-15
Friday22 messages5 participantstimes are UTC
Highlights from this day
- blind_submit — genuine question changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing, ill dig out the number 09:20
- blind_submit — the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing 10:57
- tallinn_taper — dropped the GLP-1 and stayed on this alone for 10 months, appetite held but weight barely moved 11:18
- tallinn_taper — noticed something around week 32 on monotherapy, well after i had given up expecting to 12:36
- tallinn_taper — added it to an existing tirzepatide dose rather than starting both, which made attribution possible, happy to be corrected 12:39
genuine question changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing, ill dig out the number
⚠️11📈9
combination for me
different not less
weekly for me, same day every week, no reason beyond habit
stopped for 16 months and the fullness went within a fortnight of the last dose
the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing
🧪8⚠️1😂9
combination GI was worse than either alone for me, which is not what i had read anywhere
thats the phase 3 one
does amylin do something about fullness that the GLP-1 doesnt
did anyone find monotherapy underwhelming
did anyone add this to an existing tirzepatide dose rather than starting both
dropped the GLP-1 and stayed on this alone for 10 months, appetite held but weight barely moved
📈8
if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way
noticed something around week 32 on monotherapy, well after i had given up expecting to
😂11👀10
its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake
added it to an existing tirzepatide dose rather than starting both, which made attribution possible, happy to be corrected
is the slower titration because of nausea or something else
held mine a while
REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work, i could be wrong
amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist, ymmv
i titrated over twice as many weeks as i did on semaglutide and that was right for me