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#cagrilintide 2025-12-11

Thursday28 messages6 participantstimes are UTC
Highlights from this day
  • split_shipment — whats REDEFINE testing exactly i keep the two on separate days so if something goes wrong i have a chance of knowing which 17:16
  • turnaround_tam — the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair, not advice obviously 18:15
  • rotate_the_site — added it to an existing retatrutide dose rather than starting both, which made attribution possible, ymmv 19:15
  • turnaround_tam — its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake, thats just me 19:22
  • chlorhex — the fullness thing is the part people describe differently, food stops being interesting rather than repellent, ask me again in a month CagriSema is cagrilintide with… 21:10
SS

whats REDEFINE testing exactly
i keep the two on separate days so if something goes wrong i have a chance of knowing which

MW

update on the earlier thing 40 in 2ml gives 4mg/ml which is what i use, purely because the units come out round

TT

follow up back after 26 months, is monotherapy still a minority thing here

right so you cannot tell which of the two is doing what in a combination and i stopped pretending i could

TT

for the archive combination GI was worse than either alone for me, which is not what i had read anywhere

TT

the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair, not advice obviously

CH

amylin analogue, so its not a GLP-1 at all right

TT

lost 34lb over 8 months on the combination and i genuinely cannot apportion it

cant separate them

CH

does the fullness effect fade the way appetite suppression does

has REDEFINE reported or are people quoting earlier work

RT

is the combination just the two dosed together or a single formulation

[edited]

REDEFINE is the trial

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RT

added it to an existing retatrutide dose rather than starting both, which made attribution possible, ymmv

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TT

the nausea felt different rather than less, more fullness and less of the queasy wave

its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake, thats just me

CH

how slow are people titrating this compared to tirzepatide

CH

the fullness thing is the part people describe differently, food stops being interesting rather than repellent, ask me again in a month
CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it