separate days
#cagrilintide 2025-09-29
Monday27 messages7 participantstimes are UTC
Highlights from this day
- tenpence — the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair 23:12
- bo_bloodwork — i titrated over twice as many weeks as i did on semaglutide and that was right for me changed my mind on this, i started thinking amylin was the interesting bit and… 23:40
- ghent_gradient — two VendorInvestigate results on the same Homopeptide lot came back 99 and 97.4, closer than i expected 23:58
coming back to this nobody should copy my schedule, im describing it because people asked what a slow ramp looks like
right so the fullness thing is the part people describe differently, food stops being interesting rather than repellent
the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing
different not less
follow up 15 in 0.5ml gives 4mg/ml which is what i use, purely because the units come out round
added it to an existing semaglutide dose rather than starting both, which made attribution possible
coming back to this stopped for 1 months and the fullness went within a fortnight of the last dose
the nausea felt different rather than less, more fullness and less of the queasy wave
the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair
📉13🧊10❤️8
amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist
underwhelming honestly
REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work
whats the recon people use, 10 in 0.5ml
has REDEFINE reported or are people quoting earlier work
fullness rather than nausea
if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way
changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing
£185 for a 2 vial and it lasts me longer than the GLP-1 does at my doses
i was sceptical about monotherapy and after 20 months im still sceptical, just less so, for what its worth
anyone holding at 1.7 for a while before stepping
how do people separate which of the two is doing what in a combination
does the fullness effect fade the way appetite suppression does
i titrated over twice as many weeks as i did on semaglutide and that was right for me
changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing
you cannot tell which of the two is doing what in a combination and i stopped pretending i could
amylin analogue, so its not a GLP-1 at all right
two VendorInvestigate results on the same Homopeptide lot came back 99 and 97.4, closer than i expected