follow up is the combination just the two dosed together or a single formulation
#cagrilintide 2026-01-29
Thursday40 messages12 participantstimes are UTC
Highlights from this day
- stack_sceptic — its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake 21:40
- stack_sceptic — monotherapy was underwhelming for me and i say that as someone who wanted it to work changed my mind on this, i started thinking amylin was the interesting bit and… 21:54
- iris_imports — the fullness effect hasnt faded over 6 months, unlike my semaglutide appetite curve 22:01
- amsterdam_aliquot — the reason nausea reads differently is timing, mine arrived on the second day rather than the first, take that with a pinch of salt 22:13
£120 for a 30 vial and it lasts me longer than the GLP-1 does at my doses
amylin not glp-1
held at 15 for 9 months on monotherapy before i touched it again
its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake
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while im here is there a reason people titrate this over more weeks than the others
CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it
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the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair
its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake
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anyone holding at 2.4 for a while before stepping
is the slower titration because of nausea or something else
added it to an existing semaglutide dose rather than starting both, which made attribution possible
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follow up whats the recon people use, 40 in 5ml
monotherapy was underwhelming for me and i say that as someone who wanted it to work
changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing
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REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work, ask me again in a month
did the nausea feel different to you or just less
the fullness effect hasnt faded over 6 months, unlike my semaglutide appetite curve
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titrating dead slow
monotherapy here
did anyone find monotherapy underwhelming
the reason nausea reads differently is timing, mine arrived on the second day rather than the first, take that with a pinch of salt
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is anyone running this on its own or is it all CagriSema in here
REDEFINE is the trial
the slower titration in here is community habit as much as anything, the trials had their own schedule
amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist
separate days
if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way
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the nausea felt different rather than less, more fullness and less of the queasy wave
anyone stopped the GLP-1 and kept only this
thats the phase 3 one
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i was sceptical about monotherapy and after 3 months im still sceptical, just less so
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stopped for 21 months and the fullness went within a fortnight of the last dose
weekly for me, same day every week, no reason beyond habit
slightly off topic but did the combination change your GI compared to the GLP-1 alone
the fullness thing is the part people describe differently, food stops being interesting rather than repellent
monotherapy did work for me, just slower and smaller than i expected
cant separate them
cricket_or_footythe nausea felt different rather than less, more fullness and less of the queasy wave
you cannot tell which of the two is doing what in a combination and i stopped pretending i could
[edited]i titrated over twice as many weeks as i did on semaglutide and that was right for me
the fullness effect hasnt faded over 2 months, unlike my semaglutide appetite curve
nobody should copy my schedule, im describing it because people asked what a slow ramp looks like, anyway
Recon calculator: 40mg in 2.5ml = 4mg/ml.