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#cagrilintide 2025-08-11

Monday27 messages6 participantstimes are UTC
Highlights from this day
  • endotoxin_ed — nobody should copy my schedule, im describing it because people asked what a slow ramp looks like 21:25
  • fridge_thermo — does amylin do something about fullness that the GLP-1 doesnt 21:44
  • VialBot — Verification log updated: QYB — evidence added, status unchanged. 21:56
  • surpass_two — how do people separate which of the two is doing what in a combination 23:15
EE

monotherapy question, did appetite move for you without a GLP-1 alongside
lost 23lb over 19 months on the combination and i genuinely cannot apportion it

nobody should copy my schedule, im describing it because people asked what a slow ramp looks like

Cited study
Efficacy and Safety of Cagrilintide in Adults with Overweight or Obesity — Phase 2
The Lancet · 2021
Cagrilintide monotherapy, dose ranging. The combination trials came later.

is the nausea profile genuinely different or am i imagining it

FT

monotherapy was underwhelming for me and i say that as someone who wanted it to work

VB

Verification log updated: QYB — evidence added, status unchanged.

ST

the reason nausea reads differently is timing, mine arrived on the second day rather than the first

BV

REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work

🎉1
BV

CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it, someone check my working

BV

amylin not glp-1

fridge-temps.csv
343 rows · not retained in the public archive

underwhelming honestly

ST

is there a reason people titrate this over more weeks than the others

ST

i keep the two on separate days so if something goes wrong i have a chance of knowing which

anyone holding at 0.25 for a while before stepping

🙏8
BV

if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way

BV

the fullness effect hasnt faded over 23 months, unlike my semaglutide appetite curve, thats just me

ST

how do people separate which of the two is doing what in a combination

🤝8❤️7