cagrisema thats it
#cagrilintide 2026-03-07
Saturday58 messages11 participantstimes are UTC
Highlights from this day
- u100_pat — went slower because the first step gave me two rough days and i took that as information 15:35
- group_buy_gwen — right so 30 in 5ml gives 2mg/ml which is what i use, purely because the units come out round 16:09
- group_buy_gwen — right so is there a reason people titrate this over more weeks than the others i said earlier this year that monotherapy did nothing for me, and at a higher dose it… 16:10
- careful_claims — how slow are people titrating this compared to tirzepatide 16:59
- batch_bandit — nobody should copy my schedule, im describing it because people asked what a slow ramp looks like, not advice obviously 17:45
two VendorInvestigate results on the same MKM lot came back 99.2 and 99, closer than i expected
REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work
underwhelming honestly
separate days
slower than the others
noticed something around week 29 on monotherapy, well after i had given up expecting to
went slower because the first step gave me two rough days and i took that as information
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different not less
added it to an existing tirzepatide dose rather than starting both, which made attribution possible
nobody should copy my schedule, im describing it because people asked what a slow ramp looks like
amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist, i think
is the weekly schedule the same here
update on the earlier thing CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it
stopped for 25 months and the fullness went within a fortnight of the last dose
titrating dead slow
the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair
right so 30 in 5ml gives 2mg/ml which is what i use, purely because the units come out round
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right so is there a reason people titrate this over more weeks than the others
i said earlier this year that monotherapy did nothing for me, and at a higher dose it did something
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lost 48lb over 26 months on the combination and i genuinely cannot apportion it
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anyone got two Janoshik results on the same WXT lot for this
the reason nausea reads differently is timing, mine arrived on the second day rather than the first
Reminder for careful_claims: dose day is today. Set 3 days ago.
REDEFINE is the trial
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group_buy_gwenright so is there a reason people titrate this over more weeks than the others i said…
whats REDEFINE testing exactly
how slow are people titrating this compared to tirzepatide
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coming back to this the slower titration in here is community habit as much as anything, the trials had their own schedule
fullness rather than nausea
you cannot tell which of the two is doing what in a combination and i stopped pretending i could
thats the phase 3 one
does the fullness effect fade the way appetite suppression does
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has REDEFINE reported or are people quoting earlier work
[edited]monotherapy here
the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing
nobody should copy my schedule, im describing it because people asked what a slow ramp looks like, not advice obviously
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is 2.4 the number for this too or am i confusing compounds
*Janoshik not the other one
did the nausea feel different to you or just less
follow up i titrated over twice as many weeks as i did on semaglutide and that was right for me
its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake
anyone stopped the GLP-1 and kept only this
cant separate them
update on the earlier thing is the nausea profile genuinely different or am i imagining it
i was sceptical about monotherapy and after 25 months im still sceptical, just less so
slightly off topic but i keep the two on separate days so if something goes wrong i have a chance of knowing which
monotherapy question, did appetite move for you without a GLP-1 alongside
the reason nausea reads differently is timing, mine arrived on the second day rather than the first
changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing
is the slower titration because of nausea or something else
does amylin do something about fullness that the GLP-1 doesnt
the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing
did anyone add this to an existing tirzepatide dose rather than starting both
held mine a while
how do people separate which of the two is doing what in a combination
combination for me
cant separate them
if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way
is the combination just the two dosed together or a single formulation
*Janoshik not the other one