is the slower titration because of nausea or something else
#cagrilintide 2026-03-05
Thursday39 messages7 participantstimes are UTC
Highlights from this day
- reship_rita — is the combination just the two dosed together or a single formulation 19:48
- mhra_unlicensed — the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair 20:14
- no_appetite_nia — does amylin do something about fullness that the GLP-1 doesnt 20:25
- no_appetite_nia — CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it 20:58
the reason nausea reads differently is timing, mine arrived on the second day rather than the first
has REDEFINE reported or are people quoting earlier work
titrating dead slow
is the combination just the two dosed together or a single formulation
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monotherapy here
held mine a while
does the fullness effect fade the way appetite suppression does
is the weekly schedule the same here
the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair
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held at 1 for 6 months on monotherapy before i touched it again
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right so did anyone find monotherapy underwhelming
monotherapy question, did appetite move for you without a GLP-1 alongside
does amylin do something about fullness that the GLP-1 doesnt
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combination for me
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cant separate them
REDEFINE is the trial
the fullness thing is the part people describe differently, food stops being interesting rather than repellent
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its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake
added it to an existing cagrilintide dose rather than starting both, which made attribution possible
how do people separate which of the two is doing what in a combination
you cannot tell which of the two is doing what in a combination and i stopped pretending i could
thats the phase 3 one
cagrisema thats it
CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it
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the nausea felt different rather than less, more fullness and less of the queasy wave
is 2.4 the number for this too or am i confusing compounds
ok so dropped the GLP-1 and stayed on this alone for 14 months, appetite held but weight barely moved, take that with a pinch of salt
janoshik-b-0329.pdf
2 pages · 385 KB · not retained in the public archive
€240 for a 30 vial and it lasts me longer than the GLP-1 does at my doses
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right so how many weeks before you noticed anything on monotherapy
added it to an existing tirzepatide dose rather than starting both, which made attribution possible
weekly for me, same day every week, no reason beyond habit
did anyone add this to an existing cagrilintide dose rather than starting both
how slow are people titrating this compared to semaglutide
fullness rather than nausea
anyone stopped the GLP-1 and kept only this
lost 80lb over 7 months on the combination and i genuinely cannot apportion it
follow up 30 in 3ml gives 10mg/ml which is what i use, purely because the units come out round, take that with a pinch of salt
amylin analogue, so its not a GLP-1 at all right