i said earlier this year that monotherapy did nothing for me, and at a higher dose it did something
#cagrilintide 2026-02-04
Wednesday29 messages7 participantstimes are UTC
Highlights from this day
- first_and_last_four — is the nausea profile genuinely different or am i imagining it 13:15
- nausea_window — how many weeks before you noticed anything on monotherapy 13:26
- nausea_window — stopped for 1 months and the fullness went within a fortnight of the last dose 13:44
- endotoxin_ed — dosing them on different days made no difference i could detect 14:26
thats the phase 3 one
i titrated over twice as many weeks as i did on semaglutide and that was right for me, thats just me
combination GI was worse than either alone for me, which is not what i had read anywhere
$55 for a 10 vial and it lasts me longer than the GLP-1 does at my doses
20 in 3ml gives 10mg/ml which is what i use, purely because the units come out round
is anyone running this on its own or is it all CagriSema in here
whats REDEFINE testing exactly
is there a reason people titrate this over more weeks than the others
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*week 17 not week 6
the fullness thing is the part people describe differently, food stops being interesting rather than repellent
nobody should copy my schedule, im describing it because people asked what a slow ramp looks like, i could be wrong
did the nausea feel different to you or just less
dropped the GLP-1 and stayed on this alone for 21 months, appetite held but weight barely moved
slower than the others
[edited]anyone stopped the GLP-1 and kept only this
combination for me
changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing
for the archive monotherapy did work for me, just slower and smaller than i expected
the reason nausea reads differently is timing, mine arrived on the second day rather than the first
does amylin do something about fullness that the GLP-1 doesnt
is the nausea profile genuinely different or am i imagining it
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how many weeks before you noticed anything on monotherapy
REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work
the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing, for what its worth
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stopped for 1 months and the fullness went within a fortnight of the last dose
peptidemeter-summary-b-0114.pdf
2 pages · 560 KB · not retained in the public archive
underwhelming honestly
dosing them on different days made no difference i could detect
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amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist
noticed something around week 12 on monotherapy, well after i had given up expecting to