titrating dead slow
#cagrilintide 2026-06-30
Tuesday36 messages8 participantstimes are UTC
Highlights from this day
- panel_before_after — is anyone running this on its own or is it all CagriSema in here 14:55
- dexa_or_bia — dropped the GLP-1 and stayed on this alone for 11 months, appetite held but weight barely moved 15:05
- VialBot — Verification log updated: SWB — evidence added, status unchanged. 16:39
- willow_waits — how slow are people titrating this compared to retatrutide 17:37
held at 10 for 2 months on monotherapy before i touched it again
has REDEFINE reported or are people quoting earlier work
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different not less
update on the earlier thing does the fullness effect fade the way appetite suppression does
if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way
did the combination change your GI compared to the GLP-1 alone
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whats the recon people use, 2 in 1.5ml
REDEFINE is the trial
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monotherapy here
is anyone running this on its own or is it all CagriSema in here
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slower than the others
is the weekly schedule the same here
held mine a while
cant separate them
dropped the GLP-1 and stayed on this alone for 11 months, appetite held but weight barely moved
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anyone stopped the GLP-1 and kept only this
REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work
the fullness thing is the part people describe differently, food stops being interesting rather than repellent
cagrisema thats it
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weekly for me, same day every week, no reason beyond habit
if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way, anyway
amylin not glp-1
is the slower titration because of nausea or something else
underwhelming honestly
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Verification log updated: SWB — evidence added, status unchanged.
did anyone add this to an existing cagrilintide dose rather than starting both
combination for me
Digest for the week of 2026-01-15 has been published.
how slow are people titrating this compared to retatrutide
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added it to an existing tirzepatide dose rather than starting both, which made attribution possible
whats REDEFINE testing exactly
ok so the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair
[edited]how do people separate which of the two is doing what in a combination
the nausea felt different rather than less, more fullness and less of the queasy wave
nobody should copy my schedule, im describing it because people asked what a slow ramp looks like, n of 1 obviously
thats the phase 3 one