is the slower titration because of nausea or something else
[edited]#cagrilintide 2025-10-03
Friday26 messages6 participantstimes are UTC
Highlights from this day
- deadspace — the slower titration in here is community habit as much as anything, the trials had their own schedule 20:01
- deadspace — you cannot tell which of the two is doing what in a combination and i stopped pretending i could 20:03
- sharps_bin_sid — anyone got two Janoshik results on the same QYB lot for this 20:06
combination GI was worse than either alone for me, which is not what i had read anywhere
the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing
the slower titration in here is community habit as much as anything, the trials had their own schedule
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two PeptideMeter results on the same TFC lot came back 97.4 and 99, closer than i expected
you cannot tell which of the two is doing what in a combination and i stopped pretending i could
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amylin not glp-1
REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work, i think
anyone got two Janoshik results on the same QYB lot for this
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ok so i keep the two on separate days so if something goes wrong i have a chance of knowing which
does amylin do something about fullness that the GLP-1 doesnt
i said earlier this year that monotherapy did nothing for me, and at a higher dose it did something
15 in 5ml gives 4mg/ml which is what i use, purely because the units come out round
added it to an existing semaglutide dose rather than starting both, which made attribution possible
is anyone running this on its own or is it all CagriSema in here
monotherapy here
the fullness effect hasnt faded over 5 months, unlike my semaglutide appetite curve, i have it written down somewhere
whats the recon people use, 5 in 1ml
is the combination just the two dosed together or a single formulation
did the combination change your GI compared to the GLP-1 alone
anyone dosing this on a different day to their tirzepatide
the nausea felt different rather than less, more fullness and less of the queasy wave
did the nausea feel different to you or just less
slightly off topic but whats REDEFINE testing exactly
cagrisema thats it
REDEFINE is the trial