does amylin do something about fullness that the GLP-1 doesnt
#cagrilintide 2026-04-17
Friday51 messages10 participantstimes are UTC
Highlights from this day
- warsaw_vial — is the slower titration because of nausea or something else the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing 14:41
- evidence_or_not — dosing them on different days made no difference i could detect 15:22
- private_script_pri — went slower because the first step gave me two rough days and i took that as information 18:40
has REDEFINE reported or are people quoting earlier work
[edited]is the combination just the two dosed together or a single formulation
titrating dead slow
is the slower titration because of nausea or something else
the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing
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whats the recon people use, 10 in 1ml
stopped for 20 months and the fullness went within a fortnight of the last dose
follow up dropped the GLP-1 and stayed on this alone for 14 months, appetite held but weight barely moved, take that with a pinch of salt
if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way
cant separate them
how do people separate which of the two is doing what in a combination
back after 3 months, is monotherapy still a minority thing here
anyone dosing this on a different day to their semaglutide
noticed something around week 12 on monotherapy, well after i had given up expecting to
its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake
dosing them on different days made no difference i could detect
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how slow are people titrating this compared to cagrilintide
monotherapy question, did appetite move for you without a GLP-1 alongside
amylin analogue, so its not a GLP-1 at all right
is there a reason people titrate this over more weeks than the others
lost 41lb over 1 months on the combination and i genuinely cannot apportion it
cagrisema thats it
i titrated over twice as many weeks as i did on semaglutide and that was right for me
anyone got two Medutest results on the same WXT lot for this
is the weekly schedule the same here
i was sceptical about monotherapy and after 25 months im still sceptical, just less so
the fullness effect hasnt faded over 4 months, unlike my semaglutide appetite curve
did anyone add this to an existing cagrilintide dose rather than starting both
two Medutest results on the same FGP lot came back 98.1 and 99.2, closer than i expected
for the archive the fullness thing is the part people describe differently, food stops being interesting rather than repellent
weekly for me, same day every week, no reason beyond habit
is anyone running this on its own or is it all CagriSema in here
monotherapy did work for me, just slower and smaller than i expected
fullness rather than nausea
held mine a while
thats the phase 3 one
*Medutest not the other one
monotherapy here
how many weeks before you noticed anything on monotherapy
i keep the two on separate days so if something goes wrong i have a chance of knowing which
10 in 2.5ml gives 10mg/ml which is what i use, purely because the units come out round
added it to an existing retatrutide dose rather than starting both, which made attribution possible
combination for me
$72 for a 15 vial and it lasts me longer than the GLP-1 does at my doses, we shall see
amylin not glp-1
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anyone stopped the GLP-1 and kept only this
the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing
went slower because the first step gave me two rough days and i took that as information
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the slower titration in here is community habit as much as anything, the trials had their own schedule
REDEFINE is the trial
i said earlier this year that monotherapy did nothing for me, and at a higher dose it did something, take that with a pinch of salt
CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it
held at 12 for 7 months on monotherapy before i touched it again, anyway
separate days
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