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#cagrilintide 2025-03-22

Saturday10 messages2 participantstimes are UTC
Highlights from this day
  • reta_resting_hr — you cannot tell which of the two is doing what in a combination and i stopped pretending i could, ill dig out the number 12:37
  • reta_resting_hr — dosing them on different days made no difference i could detect, we shall see 12:43
  • evidence_or_not — added it to an existing retatrutide dose rather than starting both, which made attribution possible i was sceptical about monotherapy and after 6 months im still… 13:00
RR

you cannot tell which of the two is doing what in a combination and i stopped pretending i could, ill dig out the number

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RR

dosing them on different days made no difference i could detect, we shall see

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CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it

monotherapy was underwhelming for me and i say that as someone who wanted it to work

anyone stopped the GLP-1 and kept only this

2 in 0.5ml gives 4mg/ml which is what i use, purely because the units come out round

i keep the two on separate days so if something goes wrong i have a chance of knowing which

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REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work

added it to an existing retatrutide dose rather than starting both, which made attribution possible
i was sceptical about monotherapy and after 6 months im still sceptical, just less so

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