combination for me
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#cagrilintide 2025-05-18
Sunday30 messages7 participantstimes are UTC
Highlights from this day
- verify_or_dont — anyone stopped the GLP-1 and kept only this 20:57
- eight_mm — noticed something around week 25 on monotherapy, well after i had given up expecting to 21:27
- net_peptide — update on the earlier thing held at 2.4 for 4 months on monotherapy before i touched it again 22:05
- deamidation — genuine question amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist 22:07
- net_peptide — dosing them on different days made no difference i could detect added it to an existing semaglutide dose rather than starting both, which made attribution possible 22:27
the slower titration in here is community habit as much as anything, the trials had their own schedule
dropped the GLP-1 and stayed on this alone for 20 months, appetite held but weight barely moved
20:27tenpence pinned a message
is there a reason people titrate this over more weeks than the others
amylin not glp-1
weights-monthly.csv
442 rows · not retained in the public archive
fullness rather than nausea
monotherapy here
went slower because the first step gave me two rough days and i took that as information
[edited]did anyone add this to an existing cagrilintide dose rather than starting both
*Medutest not the other one
anyone stopped the GLP-1 and kept only this
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*Medutest not the other one
if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way
anyone holding at 2.5 for a while before stepping
did the nausea feel different to you or just less
whats REDEFINE testing exactly
right so how do people separate which of the two is doing what in a combination
noticed something around week 25 on monotherapy, well after i had given up expecting to
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underwhelming honestly
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REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work
update on the earlier thing held at 2.4 for 4 months on monotherapy before i touched it again
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genuine question amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist
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titrating dead slow
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i said earlier this year that monotherapy did nothing for me, and at a higher dose it did something
dosing them on different days made no difference i could detect
added it to an existing semaglutide dose rather than starting both, which made attribution possible
its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake
is the slower titration because of nausea or something else
22:58tenpence pinned a message to this channel