titrating dead slow
#cagrilintide 2025-05-31
Saturday33 messages7 participantstimes are UTC
Highlights from this day
- abdo_two_inch — monotherapy question, did appetite move for you without a GLP-1 alongside 12:32
- karl_fischer — amylin analogue, so its not a GLP-1 at all right 12:33
- septum_sal — is the slower titration because of nausea or something else changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing 14:30
- septum_sal — does amylin do something about fullness that the GLP-1 doesnt 14:32
- VialBot — Verification log updated: FGP — evidence added, status unchanged. 16:00
does the fullness effect fade the way appetite suppression does
separate days
i titrated over twice as many weeks as i did on semaglutide and that was right for me
did anyone find monotherapy underwhelming
how many weeks before you noticed anything on monotherapy
monotherapy question, did appetite move for you without a GLP-1 alongside
😂11👍6📈7
amylin analogue, so its not a GLP-1 at all right
❤️5🎉2
went slower because the first step gave me two rough days and i took that as information
👀2
the slower titration in here is community habit as much as anything, the trials had their own schedule
[edited]is the nausea profile genuinely different or am i imagining it
changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing, ill dig out the number
is anyone running this on its own or is it all CagriSema in here
thats the phase 3 one
monotherapy here
is the slower titration because of nausea or something else
changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing
does amylin do something about fullness that the GLP-1 doesnt
😂3✅8👀1
whats the recon people use, 20 in 5ml
slower than the others
is the combination just the two dosed together or a single formulation
did the nausea feel different to you or just less
CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it
[edited]monotherapy was underwhelming for me and i say that as someone who wanted it to work, someone check my working
REDEFINE is the trial
you cannot tell which of the two is doing what in a combination and i stopped pretending i could
🙏1
how slow are people titrating this compared to tirzepatide
REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work, take that with a pinch of salt
underwhelming honestly
amylin not glp-1
how do people separate which of the two is doing what in a combination
Verification log updated: FGP — evidence added, status unchanged.
anyone stopped the GLP-1 and kept only this
held mine a while