slightly off topic but the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair
#cagrilintide 2025-06-13
Friday28 messages7 participantstimes are UTC
Highlights from this day
- VialBot — New independent result logged — Homopeptide, lot SG-1177, purity 98.6% (Medutest). 20:47
- seoul_swirl — added it to an existing tirzepatide dose rather than starting both, which made attribution possible 21:10
- warsaw_vial — stopped for 23 months and the fullness went within a fortnight of the last dose 21:35
- retention_time — update on the earlier thing two Janoshik results on the same SWB lot came back 98.1 and 96.8, closer than i expected 21:38
- retention_time — the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing 23:07
separate days
New independent result logged — Homopeptide, lot SG-1177, purity 98.6% (Medutest).
different not less
you cannot tell which of the two is doing what in a combination and i stopped pretending i could
fullness rather than nausea
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REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work
added it to an existing tirzepatide dose rather than starting both, which made attribution possible
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dropped the GLP-1 and stayed on this alone for 26 months, appetite held but weight barely moved
sorry to jump in anyone got two VendorInvestigate results on the same ERP lot for this
REDEFINE is the trial
stopped for 23 months and the fullness went within a fortnight of the last dose
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changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing, i could be wrong
update on the earlier thing two Janoshik results on the same SWB lot came back 98.1 and 96.8, closer than i expected
held mine a while
did anyone find monotherapy underwhelming
i was sceptical about monotherapy and after 10 months im still sceptical, just less so
underwhelming honestly
combination for me
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held at 15 for 4 months on monotherapy before i touched it again, ask me again in a month
did the combination change your GI compared to the GLP-1 alone
went slower because the first step gave me two rough days and i took that as information
i titrated over twice as many weeks as i did on semaglutide and that was right for me
thats the phase 3 one
whats the recon people use, 2 in 2.5ml
the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing
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is the combination just the two dosed together or a single formulation