sterility and endotoxin are separate tests and almost nobody runs either on research material
#coa-reading 2025-09-16
Tuesday12 messages3 participantstimes are UTC
Highlights from this day
- u100_pat — genuine question a supplier certificate on its own is a starting point, not evidence. that is the whole reason the verification channel exists 20:11
- cat_on_the_tray — the certificate from BCH is the one i use to teach this because it actually has a populated impurity table, someone check my working 20:12
- u100_pat — i have never seen a research certificate with an endotoxin result on it. not once i was wrong about this for a year: area percent under-reports nothing, it just… 20:15
- area_percent — an identical chromatogram on two different lots is the single biggest tell there is 20:52
genuine question a supplier certificate on its own is a starting point, not evidence. that is the whole reason the verification channel exists
the certificate from BCH is the one i use to teach this because it actually has a populated impurity table, someone check my working
a lab that reports "greater than 98%" rather than a number is telling you they did not integrate carefully
i have never seen a research certificate with an endotoxin result on it. not once
i was wrong about this for a year: area percent under-reports nothing, it just answers a different question than assay does
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thats a real table
the paperwork can be perfect and the vial can still be light. weigh it
the related substances table is the interesting part. a row of "not detected" means they did not look hard
an identical chromatogram on two different lots is the single biggest tell there is
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whats the minimum a certificate has to have before you take it seriously
how do you verify a certificate is actually from the lab it says
certificate is dated before the lot date, is that just sloppiness