residual solvents matter more than people think for anything that went through a lot of purification steps
#coa-reading 2025-10-20
Monday14 messages4 participantstimes are UTC
Highlights from this day
- void_volume — if the certificate date precedes the lot date, ask. sometimes it is sloppiness and sometimes it is not 21:05
- void_volume — the honest summary is that a certificate tells you what the supplier says about a lot they chose to test 21:08
- mhra_unlicensed — sterility and endotoxin are separate tests and almost nobody runs either on research material if the certificate date precedes the lot date, ask. sometimes it is… 21:38
update from 3 months ago: started asking every supplier for water content and about half now include it, thats just me
is endotoxin ever tested on research material
i asked CPC for the method and they sent it. that alone put them ahead of most
not detected means nothing
looks re-dated
thats a real table
thats a tell
if you only read one line on a certificate, read the lot number. if you read two, read the assay
the paperwork can be perfect and the vial can still be light. weigh it
if the certificate date precedes the lot date, ask. sometimes it is sloppiness and sometimes it is not
📈12🧪1⚠️16
the honest summary is that a certificate tells you what the supplier says about a lot they chose to test
purity is what fraction of the contents is the target. assay is how many mg are actually there. different questions
sterility and endotoxin are separate tests and almost nobody runs either on research material
if the certificate date precedes the lot date, ask. sometimes it is sloppiness and sometimes it is not
thats the counterion