Verification log updated: GGPeps — evidence added, status unchanged.
#dosing-titration 2024-02-15
Thursday26 messages6 participantstimes are UTC
Highlights from this day
- VialBot — Verification log updated: GGPeps — evidence added, status unchanged. 10:11
- mg_per_ml — small steps are better than big ones and the only reason people take big ones is impatience 12:56
- lot_number_lou — do you escalate on the calendar or on how you feel 15:16
- slow.taper — i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat 15:27
update from 5 months ago: held at the same dose the whole time and still losing slowly
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you do not have to escalate at all. that is a real option that gets forgotten
stepping back down on purpose is a completely reasonable move and this channel should say so more often, ymmv
i have been at 0.25 for 17 months and honestly i have stopped wanting to move
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pick a day and stick to it
i hold for two months minimum before i decide a dose has stopped doing anything
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
with a roughly seven day half-life you are near steady state after about five weeks at a dose, for what its worth
small steps are better than big ones and the only reason people take big ones is impatience
U-100 syringe: 1 unit = 0.01 ml
10u = 0.10 ml
25u = 0.25 ml
50u = 0.50 ml
100u = 1.00 ml
mg drawn = ml drawn x mg/mlanyone here split their weekly into two and would they do it again
whats your rule for when a side effect means hold rather than push
coming down from 15 to 2.4, how bad is the appetite rebound
if it "stopped working after four days" that is almost never pharmacokinetics
came down, no regrets
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
slightly off topic but whats the longest anyone has stayed on one dose
plateau versus set point is not answerable in under six months of data
split dosing has no trial behind it. people here do it and report on it, thats all
do you escalate on the calendar or on how you feel
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mg15:21chlorhex pinned a message
whats the smallest step anyone has managed between doses
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
if you are asking whether to go up, the fact you are asking usually means not yet
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice