vialroom

#dosing-titration 2024-02-26

Monday17 messages3 participantstimes are UTC
Highlights from this day
  • u100_pat — the trials escalated on a fixed schedule because a trial has to. you are not a trial the people who do best here are almost always the ones going slowest 20:45
  • slow.taper — with a roughly seven day half-life you are near steady state after about five weeks at a dose 21:00
  • slow.taper — the honest answer is that most of us are running protocols nobody has ever studied 21:03
  • apob_over_ldl — i log dose, day, weight and one line about how the week felt. thats enough to make decisions on 21:19
  • slow.taper — i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat 21:56
ST

i went up too fast and im paying for it, do i drop back or ride it out

U1

does a missed week reset anything or do you just carry on

U1

is week 21 too early to be thinking about the next step

the trials escalated on a fixed schedule because a trial has to. you are not a trial
the people who do best here are almost always the ones going slowest

ST

with a roughly seven day half-life you are near steady state after about five weeks at a dose

end of week thing

the honest answer is that most of us are running protocols nobody has ever studied

Cited study
Effect of Continued Weekly Semaglutide vs Placebo on Weight Loss Maintenance (STEP 4)
JAMA · 2021
The withdrawal arm. This is the trial to read before you plan to stop.

came down from a treatment dose to maintenance over about three months and it was uneventful

AO

i log dose, day, weight and one line about how the week felt. thats enough to make decisions on

how do you tell a plateau from just being at your set point

ST

i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat

👀14👍1
AO

dose day drift is mostly harmless with a weekly compound, but pick a day and defend it

do you escalate on the calendar or on how you feel

coming down from 1 to 2, how bad is the appetite rebound