#dosing-titration 2024-05-04

Saturday16 messages4 participantstimes are UTC

Highlights from this day

u100_pat — small steps are better than big ones and the only reason people take big ones is impatience 16:46
point_two_five — coming back to this the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess 17:27
taper_tess — with a roughly seven day half-life you are near steady state after about five weeks at a dose 17:28
u100_pat — if it "stopped working after four days" that is almost never pharmacokinetics 18:19
u100_pat — plateau versus set point is not answerable in under six months of data 18:23

16:37point_two_five joined

update from 2 months ago: held at the same dose the whole time and still losing slowly

the people who do best here are almost always the ones going slowest

[edited]

small steps are better than big ones and the only reason people take big ones is impatience

end of week thing

coming back to this the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess

with a roughly seven day half-life you are near steady state after about five weeks at a dose

wk 1-4    0.25mg
wk 5-10   0.50mg   (held 2 extra weeks)
wk 11-14  1.00mg
wk 15-26  1.70mg   (held, long)
wk 27+    2.40mg

if the current dose is still working, going up is spending headroom you might want later

too early imo

i went from 10 to 1 and honestly could not tell the difference in appetite

*PeptideMeter not the other one

you do not have to escalate at all. that is a real option that gets forgotten

how much does the last dose still matter 8 days later

if it "stopped working after four days" that is almost never pharmacokinetics

steady state is 5 weeks

plateau versus set point is not answerable in under six months of data

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