is week 24 too early to be thinking about the next step
#dosing-titration 2024-07-06
Saturday43 messages8 participantstimes are UTC
Highlights from this day
- coa_or_cope — with a roughly seven day half-life you are near steady state after about five weeks at a dose dose day drift is mostly harmless with a weekly compound, but pick a day… 16:56
- VialBot — Digest for the week of 2024-01-01 has been published. 17:38
- deadspace — i log dose, day, weight and one line about how the week felt. thats enough to make decisions on 18:18
- coa_or_cope — if you are asking whether to go up, the fact you are asking usually means not yet 18:19
- per_mg_pete — slightly off topic but is there a point where going up stops buying you anything 18:50
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
no trial for that
💀5✅4
not advice
you do not have to escalate at all. that is a real option that gets forgotten, we shall see
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
stepping back down on purpose is a completely reasonable move and this channel should say so more often
plateau versus set point is not answerable in under six months of data
do you escalate on the calendar or on how you feel
steady state is 5 weeks
thats noise
half life is a week
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
with a roughly seven day half-life you are near steady state after about five weeks at a dose
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
🔥12
thats anecdote
nobody here can tell you what dose to be on and the ones who try get corrected
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
Digest for the week of 2024-01-01 has been published.
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
[edited]update on the earlier thing my titration ladder took 16 months to climb and i would do it slower again
is there any actual reason to escalate every 4 weeks other than the trial did it
✅2
came down, no regrets
i escalate on symptoms. if the current dose is still doing something i stay on it
thats normal
hold
❤️16🧊8
small steps are better than big ones and the only reason people take big ones is impatience, we shall see
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
🔥11⚠️8
if you are asking whether to go up, the fact you are asking usually means not yet
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
i would hold
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
coming back to this i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
held for months
👀11
whats a sensible maintenance dose after a year at treatment dose
n of 1
slightly off topic but is there a point where going up stops buying you anything
🎉18📈5
i drifted from sunday to wednesday over a year and only noticed when i checked the log
whats the longest anyone has stayed on one dose
coming down from 1.7 to 7.5, how bad is the appetite rebound
anyone here split their weekly into two and would they do it again
i have been at 10 for 23 months and honestly i have stopped wanting to move
update from 9 months ago: held at the same dose the whole time and still losing slowly
*Medutest not the other one