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#dosing-titration 2024-09-09
Monday35 messages10 participantstimes are UTC
Highlights from this day
- karl_fischer — a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored the honest answer is that most of us are running… 18:58
- non_scale_win — stepping back down on purpose is a completely reasonable move and this channel should say so more often, ymmv 20:14
- night_pin — anyone here split their weekly into two and would they do it again 20:55
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
the honest answer is that most of us are running protocols nobody has ever studied
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do you count from injection day or from when you actually felt it
i drifted from sunday to wednesday over a year and only noticed when i checked the log
update on the earlier thing i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
if it "stopped working after four days" that is almost never pharmacokinetics
i went from 12 to 5 and honestly could not tell the difference in appetite
split dosing has no trial behind it. people here do it and report on it, thats all
holding is not failing. most people here who lasted two years held at least one dose for months
genuine question how do you tell a plateau from just being at your set point
do you escalate on the calendar or on how you feel
go slower
two weeks is nothing
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
the honest answer is that most of us are running protocols nobody has ever studied
for the archive if i took it 4 days late do i shift the schedule or go back to the old day
came down from a treatment dose to maintenance over about three months and it was uneventful
thats noise
whats the smallest step anyone has managed between doses
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
stepping back down on purpose is a completely reasonable move and this channel should say so more often, ymmv
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with a roughly seven day half-life you are near steady state after about five weeks at a dose
i escalate on symptoms. if the current dose is still doing something i stay on it
came down, no regrets
pick a day and stick to it
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
anyone here split their weekly into two and would they do it again
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)😂17
Archive lookup: night_pin first appears in this channel on 2024-01-01.
end of week thing
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appetite returning at the end of the week is extremely common and is not the dose failing
steady state is 5 weeks
*week 32 not week 5
the people who do best here are almost always the ones going slowest
is there a trial anywhere that studied twice weekly, or is it all anecdote
right so update question: did anyone who held for 22 months regret it
i hold for two months minimum before i decide a dose has stopped doing anything