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#dosing-titration 2024-09-25
Wednesday36 messages5 participantstimes are UTC
Highlights from this day
- taper_tess — anyone here split their weekly into two and would they do it again 15:46
- one_variable — whats a sensible maintenance dose after a year at treatment dose 17:55
- one_variable — dose day drift is mostly harmless with a weekly compound, but pick a day and defend it holding is not failing. most people here who lasted two years held at least one… 17:57
- sunday_shot — what does the room think about jumping a rung to catch up 21:01
anyone here split their weekly into two and would they do it again
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thats normal
right so how long did you hold at 2.5 before you moved up
update on the earlier thing anyone tracked whether a smaller more frequent dose changed their side effects
not advice
if i took it 3 days late do i shift the schedule or go back to the old day
with a roughly seven day half-life you are near steady state after about five weeks at a dose
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
came down, no regrets
i have been at 10 for 3 months and honestly i have stopped wanting to move
nobody here can tell you what dose to be on and the ones who try get corrected
pick a day and stick to it
how do you tell a plateau from just being at your set point
appetite returning at the end of the week is extremely common and is not the dose failing
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
right so i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
the ladder in the trials is a starting point, not a schedule you owe anyone
half life is a week
two weeks is nothing
the honest answer is that most of us are running protocols nobody has ever studied
whats a sensible maintenance dose after a year at treatment dose
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follow up i escalate on symptoms. if the current dose is still doing something i stay on it
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
holding is not failing. most people here who lasted two years held at least one dose for months
the trials escalated on a fixed schedule because a trial has to. you are not a trial
right so plateau versus set point is not answerable in under six months of data, i think
steady state is 5 weeks
if it "stopped working after four days" that is almost never pharmacokinetics
coming down from 7.5 to 0.25, how bad is the appetite rebound
end of week thing
19:45quiet.hours pinned a message
the ladder in the trials is a starting point, not a schedule you owe anyone
update on the earlier thing is week 5 too early to be thinking about the next step
came down from a treatment dose to maintenance over about three months and it was uneventful
what does the room think about jumping a rung to catch up
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