i would hold
#dosing-titration 2024-09-29
Sunday47 messages7 participantstimes are UTC
Highlights from this day
update from 24 months ago: held at the same dose the whole time and still losing slowly, from memory
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held for months
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thats anecdote
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coming down from 1 to 2.5, how bad is the appetite rebound
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the people who do best here are almost always the ones going slowest
do you count from injection day or from when you actually felt it
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
small steps are better than big ones and the only reason people take big ones is impatience
end of week thing
the ladder in the trials is a starting point, not a schedule you owe anyone
my titration ladder took 16 months to climb and i would do it slower again, i think
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quick one if it "stopped working after four days" that is almost never pharmacokinetics
split dosing has no trial behind it. people here do it and report on it, thats all
split dosing has no trial behind it. people here do it and report on it, thats all
does a missed week reset anything or do you just carry on
is week 20 too early to be thinking about the next step
i drifted from sunday to wednesday over a year and only noticed when i checked the log
plateau versus set point is not answerable in under six months of data
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for the archive i have been at 0.25 for 6 months and honestly i have stopped wanting to move
how do you tell a plateau from just being at your set point
steady state is 5 weeks
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it, i could be wrong
thats noise
i hold for two months minimum before i decide a dose has stopped doing anything
holding is not failing. most people here who lasted two years held at least one dose for months
if you are asking whether to go up, the fact you are asking usually means not yet
no trial for that
has anyone gone up and then straight back down and been glad they tried
half life is a week
pick a day and stick to it
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you do not have to escalate at all. that is a real option that gets forgotten
genuine question if you are going up because the scale stalled for two weeks, wait. two weeks is noise
if the current dose is still working, going up is spending headroom you might want later
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
stepping back down on purpose is a completely reasonable move and this channel should say so more often
is there a trial anywhere that studied twice weekly, or is it all anecdote
go slower
if i hold at 2.4 indefinitely am i losing anything
unrelated but came down from a treatment dose to maintenance over about three months and it was uneventful
i went from 1.7 to 5 and honestly could not tell the difference in appetite
too early imo
appetite returning at the end of the week is extremely common and is not the dose failing, someone check my working
with a roughly seven day half-life you are near steady state after about five weeks at a dose
not advice
pick a day and stick to it