whats a sensible maintenance dose after a year at treatment dose
#dosing-titration 2024-11-17
Sunday44 messages9 participantstimes are UTC
Highlights from this day
- taper_tess — plateau versus set point is not answerable in under six months of data 10:35
- taper_or_not — came down from a treatment dose to maintenance over about three months and it was uneventful 12:50
- taper_or_not — unrelated but update question: did anyone who held for 5 months regret it nobody here can tell you what dose to be on and the ones who try get corrected 13:04
coming down from 0.25 to 10, how bad is the appetite rebound
i escalate on symptoms. if the current dose is still doing something i stay on it, happy to be corrected
Verification log updated: KP — evidence added, status unchanged.
split dosing has no trial behind it. people here do it and report on it, thats all
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you do not have to escalate at all. that is a real option that gets forgotten
my titration ladder took 17 months to climb and i would do it slower again
plateau versus set point is not answerable in under six months of data
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i drifted from sunday to wednesday over a year and only noticed when i checked the log
*Medutest not the other one
two weeks is nothing
how do you tell a plateau from just being at your set point
steady state is 5 weeks
holding is not failing. most people here who lasted two years held at least one dose for months
no trial for that
my dose day has drifted 4 days later over 26 months, does it matter
has anyone gone up and then straight back down and been glad they tried
[edited]if you are asking whether to go up, the fact you are asking usually means not yet
quick one if i hold at 15 indefinitely am i losing anything
coming back to this small steps are better than big ones and the only reason people take big ones is impatience, ymmv
with a roughly seven day half-life you are near steady state after about five weeks at a dose
Testing queue: 2 submissions open, 65 awaiting dispatch.
the ladder in the trials is a starting point, not a schedule you owe anyone
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
i have been at 7.5 for 12 months and honestly i have stopped wanting to move
came down from a treatment dose to maintenance over about three months and it was uneventful
U-100 syringe: 1 unit = 0.01 ml
10u = 0.10 ml
25u = 0.25 ml
50u = 0.50 ml
100u = 1.00 ml
mg drawn = ml drawn x mg/ml👍2
if i took it 7 days late do i shift the schedule or go back to the old day
thats noise
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
unrelated but update question: did anyone who held for 5 months regret it
nobody here can tell you what dose to be on and the ones who try get corrected
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
came down, no regrets
go slower
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is week 3 too early to be thinking about the next step
whats the smallest step anyone has managed between doses
how long did you hold at 1.7 before you moved up
what does the room think about jumping a rung to catch up
is there a trial anywhere that studied twice weekly, or is it all anecdote
the trials escalated on a fixed schedule because a trial has to. you are not a trial
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat, thats one data point
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end of week thing
for the archive anyone tracked whether a smaller more frequent dose changed their side effects
if it "stopped working after four days" that is almost never pharmacokinetics, someone check my working
too early imo
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
i went up too fast and im paying for it, do i drop back or ride it out