follow up i went from 0.5 to 12 and honestly could not tell the difference in appetite
#dosing-titration 2025-01-03
Friday44 messages9 participantstimes are UTC
Highlights from this day
- stack_sceptic — whats your rule for when a side effect means hold rather than push 03:52
- amylin_amy — i escalate on symptoms. if the current dose is still doing something i stay on it 04:10
- triple_ag_tom — if the current dose is still working, going up is spending headroom you might want later 05:44
- dose_day_drift — the ladder in the trials is a starting point, not a schedule you owe anyone 05:47
the people who do best here are almost always the ones going slowest, for what its worth
how much does the last dose still matter 4 days later
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i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
i hold for two months minimum before i decide a dose has stopped doing anything
do you tell your prescriber you held or do you just hold
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sorry to jump in the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
thats anecdote
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the honest answer is that most of us are running protocols nobody has ever studied
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two weeks is nothing
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appetite returning at the end of the week is extremely common and is not the dose failing
update on the earlier thing update question: did anyone who held for 11 months regret it
whats your rule for when a side effect means hold rather than push
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whats a sensible maintenance dose after a year at treatment dose
back_from_awayfollow up i went from 0.5 to 12 and honestly could not tell the difference in appetite
nobody here can tell you what dose to be on and the ones who try get corrected
you do not have to escalate at all. that is a real option that gets forgotten
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
i escalate on symptoms. if the current dose is still doing something i stay on it
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pick a day and stick to it
end of week thing
quick one came down from a treatment dose to maintenance over about three months and it was uneventful
i drifted from sunday to wednesday over a year and only noticed when i checked the log
follow up if it "stopped working after four days" that is almost never pharmacokinetics, ymmv
update from 14 months ago: held at the same dose the whole time and still losing slowly
thats noise
is there a trial anywhere that studied twice weekly, or is it all anecdote
plateau versus set point is not answerable in under six months of data
i have been at 1.7 for 9 months and honestly i have stopped wanting to move
if the current dose is still working, going up is spending headroom you might want later
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unrelated but the trials escalated on a fixed schedule because a trial has to. you are not a trial
the ladder in the trials is a starting point, not a schedule you owe anyone
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i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
too early imo
half life is a week
if i hold at 2.4 indefinitely am i losing anything
i would hold
sorry to jump in stepping back down on purpose is a completely reasonable move and this channel should say so more often
holding is not failing. most people here who lasted two years held at least one dose for months
small steps are better than big ones and the only reason people take big ones is impatience
sorry to jump in is there a point where going up stops buying you anything
has anyone gone up and then straight back down and been glad they tried
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no trial for that
follow up is week 26 too early to be thinking about the next step
genuine question if you are going up because the scale stalled for two weeks, wait. two weeks is noise