for the archive if it "stopped working after four days" that is almost never pharmacokinetics
#dosing-titration 2025-01-18
Saturday35 messages8 participantstimes are UTC
Highlights from this day
- two_ml_two — is there a trial anywhere that studied twice weekly, or is it all anecdote 18:08
- step_one_sian — plateau versus set point is not answerable in under six months of data 18:25
- step_one_sian — follow up coming down from 12 to 0.5, how bad is the appetite rebound 18:38
- VialBot — Verification log updated: SSA — evidence added, status unchanged. 20:10
not advice
held for months
unrelated but if you are going up because the scale stalled for two weeks, wait. two weeks is noise
update on the earlier thing the honest answer is that most of us are running protocols nobody has ever studied
n of 1
is there a trial anywhere that studied twice weekly, or is it all anecdote
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)came down from a treatment dose to maintenance over about three months and it was uneventful
i went up too fast and im paying for it, do i drop back or ride it out
hold
plateau versus set point is not answerable in under six months of data
📉12⚠️7
follow up coming down from 12 to 0.5, how bad is the appetite rebound
👍1💀6😂11
half life is a week
thats noise
i escalate on symptoms. if the current dose is still doing something i stay on it
i hold for two months minimum before i decide a dose has stopped doing anything
the honest answer is that most of us are running protocols nobody has ever studied
📈1👍4
slightly off topic but stepping back down on purpose is a completely reasonable move and this channel should say so more often
genuine question if i hold at 2.4 indefinitely am i losing anything
with a roughly seven day half-life you are near steady state after about five weeks at a dose
holding is not failing. most people here who lasted two years held at least one dose for months
nobody here can tell you what dose to be on and the ones who try get corrected
the ladder in the trials is a starting point, not a schedule you owe anyone
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
*that should say weekly
is week 14 too early to be thinking about the next step
unrelated but i drifted from sunday to wednesday over a year and only noticed when i checked the log, i think
right so the trials escalated on a fixed schedule because a trial has to. you are not a trial
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
[edited]Verification log updated: SSA — evidence added, status unchanged.
is it normal for appetite to come back at the end of the week
i have been at 5 for 24 months and honestly i have stopped wanting to move
pick a day and stick to it
two weeks is nothing
quick one whats your rule for when a side effect means hold rather than push
the people who do best here are almost always the ones going slowest
came down, no regrets
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
i would hold