do you count from injection day or from when you actually felt it
#dosing-titration 2025-02-11
Tuesday41 messages10 participantstimes are UTC
Highlights from this day
- stack_sceptic — is there a point where going up stops buying you anything 13:49
- apnoea_down_two — i drifted from sunday to wednesday over a year and only noticed when i checked the log 13:54
- mg_per_ml — anyone tracked whether a smaller more frequent dose changed their side effects 15:45
- pbs_pip — the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess 16:19
- provincial_pat — i went up too fast and im paying for it, do i drop back or ride it out the honest answer is that most of us are running protocols nobody has ever studied 17:03
is there a point where going up stops buying you anything
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you do not have to escalate at all. that is a real option that gets forgotten, for what its worth
steady state is 5 weeks
i hold for two months minimum before i decide a dose has stopped doing anything
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i drifted from sunday to wednesday over a year and only noticed when i checked the log
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is there a trial anywhere that studied twice weekly, or is it all anecdote
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
unrelated but whats the longest anyone has stayed on one dose
update on the earlier thing whats a sensible maintenance dose after a year at treatment dose
sorry to jump in is week 26 too early to be thinking about the next step
pick a day and stick to it
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not advice
go slower
nobody here can tell you what dose to be on and the ones who try get corrected
apnoea_down_twoi drifted from sunday to wednesday over a year and only noticed when i checked the log
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
follow up is there any actual reason to escalate every 4 weeks other than the trial did it
what does the room think about jumping a rung to catch up
too early imo
appetite returning at the end of the week is extremely common and is not the dose failing
the people who do best here are almost always the ones going slowest
whats your rule for when a side effect means hold rather than push
if you are going up because the scale stalled for two weeks, wait. two weeks is noise, anyway
anyone tracked whether a smaller more frequent dose changed their side effects
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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i have been at 2 for 7 months and honestly i have stopped wanting to move
thats noise
slightly off topic but after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
plateau versus set point is not answerable in under six months of data
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
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my dose day has drifted 2 days later over 13 months, does it matter
slightly off topic but how do you tell a plateau from just being at your set point
two weeks is nothing
i escalate on symptoms. if the current dose is still doing something i stay on it
has anyone gone up and then straight back down and been glad they tried
do you tell your prescriber you held or do you just hold
the trials escalated on a fixed schedule because a trial has to. you are not a trial, i could be wrong
thats normal
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end of week thing
U-100 syringe: 1 unit = 0.01 ml
10u = 0.10 ml
25u = 0.25 ml
50u = 0.50 ml
100u = 1.00 ml
mg drawn = ml drawn x mg/mli would hold
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
i went up too fast and im paying for it, do i drop back or ride it out
the honest answer is that most of us are running protocols nobody has ever studied
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