unrelated but i drifted from sunday to wednesday over a year and only noticed when i checked the log
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#dosing-titration 2025-03-14
Friday44 messages8 participantstimes are UTC
Highlights from this day
- first_and_last_four — the honest answer is that most of us are running protocols nobody has ever studied 19:18
- stable_not_volatile — came down from a treatment dose to maintenance over about three months and it was uneventful 19:37
- triple_ag_tom — if the current dose is still working, going up is spending headroom you might want later, still working it out 20:59
- rotate_the_site — i went up too fast and im paying for it, do i drop back or ride it out 21:42
- gall_bladder_gav — right so i log dose, day, weight and one line about how the week felt. thats enough to make decisions on, someone check my working 21:43
came down, no regrets
i would hold
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the honest answer is that most of us are running protocols nobody has ever studied
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
end of week thing
is week 20 too early to be thinking about the next step
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
the trials escalated on a fixed schedule because a trial has to. you are not a trial
came down from a treatment dose to maintenance over about three months and it was uneventful
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
holding is not failing. most people here who lasted two years held at least one dose for months
steady state is 5 weeks
n of 1
if it "stopped working after four days" that is almost never pharmacokinetics
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
what does the room think about jumping a rung to catch up
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whats your rule for when a side effect means hold rather than push
not advice
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice, we shall see
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
held for months
with a roughly seven day half-life you are near steady state after about five weeks at a dose
plateau versus set point is not answerable in under six months of data
i went from 10 to 0.25 and honestly could not tell the difference in appetite, i think
update question: did anyone who held for 17 months regret it
update from 22 months ago: held at the same dose the whole time and still losing slowly
nobody here can tell you what dose to be on and the ones who try get corrected, ill dig out the number
if you are asking whether to go up, the fact you are asking usually means not yet
too early imo
thats anecdote
medutest-report-e-2205.pdf
3 pages · 579 KB · not retained in the public archive
coming down from 7.5 to 10, how bad is the appetite rebound
if the current dose is still working, going up is spending headroom you might want later, still working it out
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if you are going up because the scale stalled for two weeks, wait. two weeks is noise, anyway
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
hold
pick a day and stick to it
i went up too fast and im paying for it, do i drop back or ride it out
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right so i log dose, day, weight and one line about how the week felt. thats enough to make decisions on, someone check my working
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two weeks is nothing
if i hold at 0.25 indefinitely am i losing anything
you do not have to escalate at all. that is a real option that gets forgotten, still working it out
how do you tell a plateau from just being at your set point
[edited]has anyone gone up and then straight back down and been glad they tried
janoshik-c-4402.pdf
2 pages · 916 KB · not retained in the public archive
is it normal for appetite to come back at the end of the week
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