plateau versus set point is not answerable in under six months of data
#dosing-titration 2025-04-06
Sunday26 messages5 participantstimes are UTC
Highlights from this day
- gradient_greg — holding is not failing. most people here who lasted two years held at least one dose for months 19:52
- triple_ag_tom — is there a trial anywhere that studied twice weekly, or is it all anecdote 20:05
- gradient_greg — is there any actual reason to escalate every 4 weeks other than the trial did it 20:21
- triple_ag_tom — my dose day has drifted 5 days later over 13 months, does it matter 20:39
holding is not failing. most people here who lasted two years held at least one dose for months
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a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
steady state is 5 weeks
is there a trial anywhere that studied twice weekly, or is it all anecdote
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came down from a treatment dose to maintenance over about three months and it was uneventful, still working it out
not advice
is there any actual reason to escalate every 4 weeks other than the trial did it
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ok so small steps are better than big ones and the only reason people take big ones is impatience
i would hold
right so my titration ladder took 14 months to climb and i would do it slower again
is week 4 too early to be thinking about the next step
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i drifted from sunday to wednesday over a year and only noticed when i checked the log
my dose day has drifted 5 days later over 13 months, does it matter
peptidemeter-summary-h-2814.pdf
2 pages · 98 KB · not retained in the public archive
anyone tracked whether a smaller more frequent dose changed their side effects
pick a day and stick to it
slightly off topic but whats the longest anyone has stayed on one dose
the people who do best here are almost always the ones going slowest
do you escalate on the calendar or on how you feel
has anyone gone up and then straight back down and been glad they tried
update question: did anyone who held for 9 months regret it
stepping back down on purpose is a completely reasonable move and this channel should say so more often
i went from 15 to 0.5 and honestly could not tell the difference in appetite
the trials escalated on a fixed schedule because a trial has to. you are not a trial, thats one data point
if it "stopped working after four days" that is almost never pharmacokinetics
go slower