a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
#dosing-titration 2025-04-13
Sunday33 messages8 participantstimes are UTC
Highlights from this day
- half_life_hal — slightly off topic but my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step 14:58
- half_life_hal — i escalate on symptoms. if the current dose is still doing something i stay on it, thats just me 15:02
- nausea_window — slightly off topic but nobody here can tell you what dose to be on and the ones who try get corrected 16:10
- VialBot — New independent result logged — QST, lot SG-1177, purity 99% (Janoshik). 18:31
if you are asking whether to go up, the fact you are asking usually means not yet
came down from a treatment dose to maintenance over about three months and it was uneventful, we shall see
if i hold at 2.4 indefinitely am i losing anything
Digest for the week of 2024-07-22 has been published.
plateau versus set point is not answerable in under six months of data
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
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end of week thing
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n of 1
slightly off topic but my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
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i would hold
i escalate on symptoms. if the current dose is still doing something i stay on it, thats just me
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i went up too fast and im paying for it, do i drop back or ride it out
if it "stopped working after four days" that is almost never pharmacokinetics
the trials escalated on a fixed schedule because a trial has to. you are not a trial, take that with a pinch of salt
if it "stopped working after four days" that is almost never pharmacokinetics
i drifted from sunday to wednesday over a year and only noticed when i checked the log
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
do you tell your prescriber you held or do you just hold
[edited]slightly off topic but nobody here can tell you what dose to be on and the ones who try get corrected
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*Medutest not the other one
what does the room think about jumping a rung to catch up
holding is not failing. most people here who lasted two years held at least one dose for months
follow up after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
update question: did anyone who held for 13 months regret it
has anyone gone up and then straight back down and been glad they tried
the people who do best here are almost always the ones going slowest
with a roughly seven day half-life you are near steady state after about five weeks at a dose
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
the ladder in the trials is a starting point, not a schedule you owe anyone
whats the smallest step anyone has managed between doses
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the honest answer is that most of us are running protocols nobody has ever studied
if the current dose is still working, going up is spending headroom you might want later
New independent result logged — QST, lot SG-1177, purity 99% (Janoshik).