stepping back down on purpose is a completely reasonable move and this channel should say so more often
#dosing-titration 2025-05-14
Wednesday39 messages8 participantstimes are UTC
Highlights from this day
- cold_pack_carla — after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice 11:54
- apob_over_ldl — with a roughly seven day half-life you are near steady state after about five weeks at a dose 12:31
- protein_floor — the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess 13:18
- protein_floor — if you are going up because the scale stalled for two weeks, wait. two weeks is noise 16:05
appetite returning at the end of the week is extremely common and is not the dose failing
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
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my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
half life is a week
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two weeks is nothing
nobody here can tell you what dose to be on and the ones who try get corrected
hold
my titration ladder took 16 months to climb and i would do it slower again
held for months
split dosing has no trial behind it. people here do it and report on it, thats all
appetite returning at the end of the week is extremely common and is not the dose failing
the honest answer is that most of us are running protocols nobody has ever studied, ymmv
too early imo
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with a roughly seven day half-life you are near steady state after about five weeks at a dose
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored, for what its worth
slightly off topic but the trials escalated on a fixed schedule because a trial has to. you are not a trial
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
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plateau versus set point is not answerable in under six months of data
sorry to jump in if you are asking whether to go up, the fact you are asking usually means not yet, not advice obviously
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anyone here split their weekly into two and would they do it again
whats the smallest step anyone has managed between doses
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thats normal
came down from a treatment dose to maintenance over about three months and it was uneventful, your mileage will differ
pick a day and stick to it
thats anecdote
i escalate on symptoms. if the current dose is still doing something i stay on it
go slower
thats noise
i went from 1.7 to 15 and honestly could not tell the difference in appetite
no trial for that
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i hold for two months minimum before i decide a dose has stopped doing anything
whats your rule for when a side effect means hold rather than push
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not advice
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
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update from 25 months ago: held at the same dose the whole time and still losing slowly
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
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i drifted from sunday to wednesday over a year and only noticed when i checked the log, take that with a pinch of salt
how long did you hold at 2.5 before you moved up
i would hold