with a roughly seven day half-life you are near steady state after about five weeks at a dose
#dosing-titration 2025-05-24
Saturday59 messages12 participantstimes are UTC
Highlights from this day
- mg_per_ml — a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored 13:24
- weather_watch — dose day drift is mostly harmless with a weekly compound, but pick a day and defend it, thats one data point holding is not failing. most people here who lasted two… 14:46
- mg_per_ml — after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice 14:56
- wrong_network — anyone tracked whether a smaller more frequent dose changed their side effects 17:56
- hair_month_four — if it "stopped working after four days" that is almost never pharmacokinetics 18:44
whats a sensible maintenance dose after a year at treatment dose
too early imo
split dosing has no trial behind it. people here do it and report on it, thats all
you do not have to escalate at all. that is a real option that gets forgotten
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
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i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
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for the archive if the current dose is still working, going up is spending headroom you might want later
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coming down from 2 to 10, how bad is the appetite rebound
i went up too fast and im paying for it, do i drop back or ride it out
if you are asking whether to go up, the fact you are asking usually means not yet
thats anecdote
appetite returning at the end of the week is extremely common and is not the dose failing, not advice obviously
is there any actual reason to escalate every 4 weeks other than the trial did it
how do you decide between holding and stepping when both feel wrong
came down, no regrets
go slower
i have been at 1 for 14 months and honestly i have stopped wanting to move
quick one update question: did anyone who held for 14 months regret it
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
stepping back down on purpose is a completely reasonable move and this channel should say so more often
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it, thats one data point
holding is not failing. most people here who lasted two years held at least one dose for months
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held for months
small steps are better than big ones and the only reason people take big ones is impatience
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
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my titration ladder took 5 months to climb and i would do it slower again
the people who do best here are almost always the ones going slowest
does a missed week reset anything or do you just carry on
if you are asking whether to go up, the fact you are asking usually means not yet
is week 29 too early to be thinking about the next step
[edited]the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
i drifted from sunday to wednesday over a year and only noticed when i checked the log
thats normal
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i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
do you tell your prescriber you held or do you just hold
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not advice
how do you tell a plateau from just being at your set point
no trial for that
is there a trial anywhere that studied twice weekly, or is it all anecdote
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
is it normal for appetite to come back at the end of the week
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my dose day has drifted 2 days later over 12 months, does it matter
follow up do you count from injection day or from when you actually felt it
whats your rule for when a side effect means hold rather than push
steady state is 5 weeks
while im here the trials escalated on a fixed schedule because a trial has to. you are not a trial
i escalate on symptoms. if the current dose is still doing something i stay on it
two weeks is nothing
i would hold
anyone tracked whether a smaller more frequent dose changed their side effects
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stepping back down on purpose is a completely reasonable move and this channel should say so more often
quick one update from 24 months ago: held at the same dose the whole time and still losing slowly, not advice obviously
coming back to this whats the longest anyone has stayed on one dose
do you escalate on the calendar or on how you feel
has anyone gone up and then straight back down and been glad they tried
i hold for two months minimum before i decide a dose has stopped doing anything
half life is a week
if i hold at 2.4 indefinitely am i losing anything
whats the smallest step anyone has managed between doses
if it "stopped working after four days" that is almost never pharmacokinetics
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