holding is not failing. most people here who lasted two years held at least one dose for months
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#dosing-titration 2025-06-05
Thursday32 messages8 participantstimes are UTC
Highlights from this day
- u100_pat — holding is not failing. most people here who lasted two years held at least one dose for months 17:15
- group_buy_gwen — anyone here split their weekly into two and would they do it again 18:11
- u100_pat — update from 13 months ago: held at the same dose the whole time and still losing slowly 18:39
- sgp_subq — the people who do best here are almost always the ones going slowest, ill dig out the number 20:17
i went from 2.4 to 0.5 and honestly could not tell the difference in appetite
plateau versus set point is not answerable in under six months of data
whats the smallest step anyone has managed between doses
appetite returning at the end of the week is extremely common and is not the dose failing
whats a sensible maintenance dose after a year at treatment dose
anyone tracked whether a smaller more frequent dose changed their side effects
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
*week 21 not week 7
steady state is 5 weeks
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with a roughly seven day half-life you are near steady state after about five weeks at a dose
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*week 32 not week 4
anyone here split their weekly into two and would they do it again
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Inter-lab diff for lot H-2814: 99.2% vs 99%. Within expected range.
no trial for that
update from 13 months ago: held at the same dose the whole time and still losing slowly
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not advice
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
whats the longest anyone has stayed on one dose
i hold for two months minimum before i decide a dose has stopped doing anything
half life is a week
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pick a day and stick to it
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nobody here can tell you what dose to be on and the ones who try get corrected
the ladder in the trials is a starting point, not a schedule you owe anyone, i could be wrong
thats noise
follow up how much does the last dose still matter 8 days later
do you tell your prescriber you held or do you just hold
does a missed week reset anything or do you just carry on
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my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
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if you are asking whether to go up, the fact you are asking usually means not yet
if the current dose is still working, going up is spending headroom you might want later, take that with a pinch of salt
coming down from 12 to 15, how bad is the appetite rebound
the people who do best here are almost always the ones going slowest, ill dig out the number
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